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Spatial genome re-organization between fetal and adult hematopoietic stem cells disq.us/t/3eepr4o

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data biorxiv.org/content/10.110…

scATAC-pro: a comprehensive workbench for single-cell chromatin accessibility sequencing data biorxiv.org/content/10.110…

Very excited to share our new preprint on pre-HSC formation in early development. Feedbacks are welcome! It's a two-years-long effort with Tan Lab (Kai Tan 🇺🇦) and Speck Lab to collect and dig into the scRNA and scATAC data and functionally validate our findings!

Very excited to share the joint work with the Speck lab to map the transcriptional regulatory circuitry during definitive embryonic hematopoiesis. Kudos to Peng, Changya and Elizabeth from both labs who did the lion's share of the work! biorxiv.org/content/10.110…

Transcriptional regulatory network controlling the ontogeny of hematopoietic stem cells biorxiv.org/content/10.110…

Very proud of our study. Technically very challenging experiments to do, dealing with rare primary hematopoietic stem cells. Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells: Cell Reports disq.us/t/3khb0fq

Our latest puplication is online! The work was a collaboration with Kai Tan Lab (Kai Tan 🇺🇦) with Gao, Peng, Changya, and our graduate student Elizabeth Howell leading the work - genesdev.cshlp.org/content/early/…

Excited to share our new method MAPLE for integrating single-cell methylome and transcriptome data based on supervised learning. biorxiv.org/content/10.110…

Great collaboration with the Speck lab.

Diverse noncoding mutations contribute to deregulation of cis-regulatory landscape in pediatric cancers advances.sciencemag.org/content/6/30/e…

Excited to share our single-cell multi-omics study of a high-risk subtype of leukemia, as part of the @NCIHTAN. Tremendous effort by multiple labs at Cancer Center @ CHOP, Penn Genetics, Penn Path & Lab Medicine, Children's Mercy, Johns Hopkins Children's Center. biorxiv viewer disq.us/t/3tchj0n

So excited to share our preprint about infant leukemia study at single-cell resolution!

Just published #OnlineFirst: Integrative bulk and #singlecell profiling of pre-manufacture T-cell populations reveals factors mediating long-term persistence of #CARTcell therapy. Kai Tan 🇺🇦 UPenn GCB Children's Hospital #immunotherapy bit.ly/3mo7EnE

Happy to share our newest study on KMT2Ar leukemia using single cell multiomics! rb.gy/c58zk8

Thanks for your nice review!

Great presentation ASH by another lab member, Changya Chen Changya on characterization of progenitor-like blasts in high risk leukemias! Great collaboration with David Teachey, Kathrin Bernt, Sarah Tasiah, Jun Yang labs! #ASH22

Excited to announce deMULTIplex2 - a powerful new classification algorithm for multiplexed scRNA-seq data from the Gartner lab and Chan Zuckerberg Biohub Network, C3STC, and UC San Francisco developed by Qin Zhu & Danny Conrad: doi.org/10.1101/2023.0…

Excited to share the first spatially resolved multiomics atlas for human bone marrow, published today in Cell. twtr.to/cJ099. Wonderful collaborations with Ling Qin Ling Qin, Charles Nelson, Martin Carroll, Ivan Maillard, Vinohd Pillai HemepathMD labs!