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We found that TRPV4 and Cx43 are primarily located in the endothelial of resistance arteries.

TRPV4 activation induced Cx43 nitrosylation.

TRPV4–Cx43 hemichannels mediate Ca2+ increases in endothelial cells in response to TRPV4 activation

Cx43 hemichannels do not contribute to NO production in endothelial cells but mediate endothelium hyperpolarization upon TRPV4 activation in intact endothelium

Maturational Stage Dependent Contributions of the Cav3.2 T-type Calcium Channel to Dentate Gyrus Granule Cell Excitability - PubMed ift.tt/5wiGrg9 From @ChannelOmics.bsky.social #IonChannels

Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2 #ionchannelshttps://ift.tt/NwPasGl From @ChannelOmics.bsky.social #IonChannels

Ball-and-chain inactivation of a human large conductance calcium-activated potassium #ionchannelshttps://ift.tt/pxTYqFl From @ChannelOmics.bsky.social #IonChannels

HCN4 channels sense temperature and determine heart rate responses to heat | Nature Communications#ionchannelshttps://ift.tt/nsh5tC8 From 👋Channelomics.bsky.social👋.bsky.social #IonChannels

Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation | Cell Death & Disease#ionchannelshttps://ift.tt/zbOe2P3 From 👋Channelomics.bsky.social👋.bsky.social #IonChannels

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery | Nature Communications#ionchannelshttps://ift.tt/mICb2gv From @ChannelOmics.bsky.social #IonChannels

Preferential allosteric modulation of Otop1 channels by small molecule compounds | Communications Biology#ionchannelshttps://ift.tt/QyNjodg From @ChannelOmics.bsky.social #IonChannels

Nicotinic acetylcholine receptor #ionchannels regulate growth hormone in pituitary somatotrophs …in tigers…ift.tt/JY3X8a7 From @ChannelOmics.bsky.social #IonChannels

Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature#ionchannelshttps://ift.tt/BtZxGV2 From @ChannelOmics.bsky.social #IonChannels

Identification of druggable binding sites and small molecules as modulators of TMC1 | Communications Biologyhttps://ift.tt/L8AoET4 From @ChannelOmics.bsky.social #IonChannels

The identification of XPR1 as a voltage- and phosphate-activated phosphate-permeable #ionchannel (never heard of it before) - Nature Communications ift.tt/NwMfDzS From @ChannelOmics.bsky.social #IonChannels

The molecular transition that confers voltage dependence to muscle contraction | Nature Communications ift.tt/VJZREH7 From @ChannelOmics.bsky.social #IonChannels

Functional expression of the T-type Cav3.2 calcium #ionchannel in female and male human dorsal root ganglion neurons | Brain | Oxford Academic ift.tt/rxOe2BR From @ChannelOmics.bsky.social #IonChannels

Mmm… 🤔 Using metaphorical considerations to benefit research on the sodium channel fast inactivation mechanism | Journal of General Physiology | Rockefeller University Press ift.tt/BxY5dQr From @ChannelOmics.bsky.social #IonChannels

ASIC #ionchannel currents in cultured primate retinal amacrine/ganglion cells - Saafir - 2025 - Physiological Reports - Wiley Online Library ift.tt/KHifTmZ From @ChannelOmics.bsky.social #IonChannels

Clinically relevant niclosamide concentrations modulate TMEM16A and CaV1.2 #ionchannels to control artery tone and capillary diameter - Kaye - British Journal of Pharmacology - Wiley Online Library ift.tt/Fatcbgm From @ChannelOmics.bsky.social #IonChannels