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Sojung Kim’s mechanistic investigation of photomediated ring contractions of N-aryl saturated heterocycles with Henrik Schwarz and Justin in collaboration with the zuerchlab and our collaborators from Abbvie and Merck is in J. Am. Chem. Soc. ! pubs.acs.org/doi/epdf/10.10…

Lysine an amine donor in transaminase-catalyzed reactions? A thrifty hack for driving equilibria! chemrxiv.org/engage/chemrxi…

Really great work by the team to avoid issues around byproduct removal associated with transaminases and develop lysine as a smart donor, plus a great scope of noncanonical branched arylalanines! #MerckChemistry Noah Dunham chemrxiv.org/engage/chemrxi…

We’re hiring in Discovery!! 💊🥼🧬 We have multiple openings in Boston, San Francisco and West Point (PA) spanning Bachelor's, Master’s, entry level PhD and PhD with experience. Go to jobs.merck.com and search for ‘Discovery Chemistry’ or ‘Peptide’! #MerckChemistry

Aminoalcohols are expressed in natural products, blockbuster pharmaceuticals, agrochemicals, and key building blocks for innumerable society-benefitting applications. See how a departure from polar bond analysis can radically simplify access to these structures on small or large

Excited that the final version of our work using lysine as a smart donor to prepare branched arylalanines is in J. Am. Chem. Soc. today! Amazing work by Noah Dunham and everyone who worked on this! #MerckChemistry RITWIKA RAY Matt Winston Yining Mikhail Reibarkh pubs.acs.org/doi/10.1021/ja…

Interested in forging carbon—nitrogen bonds? Merging photoredox and copper catalysis platforms, we can now make these bonds from alcohols. Now out in JACS! pubs.acs.org/doi/10.1021/ja…

Excited to share our newest strategy to access carbenes from aldehydes - now via radicals! Young & Jake found this highly practical, efficient, & selective way to make triangles - that even works in the presence of air or water! J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

We’re excited to share our quantitative assessment of the potential impact of skeletal edits, now on ChemRxiv! This cheminformatic platform was developed with Lucas Karas from Sigman Lab and Reilly Eason & Charles Yeung at #MerckChemistry. tinyurl.com/yc4jev9k

Stradiotto group PDF Kathleen Morrison just back from visiting our collaborator (Charles Yeung) at Merck to learn about HTE and to share her expertise on nickel catalysis 👍

As part of our ongoing collaboration with Charles Yeung at Merck, we found a new way to promote alkene carboxy-alkylation that exploits the unique chemoselectivity profile of CO2•- accessed from formate! Check it out: pubs.acs.org/doi/full/10.10… Congrats to all the authors!!

Alkene Carboxy-Alkylation via CO2•– | Journal of the American Chemical Society Zach Wickens Wickens Group UW-Madison Chemistry UW–Madison Total Synthesis and Methodology Highlights #Alkene #CarboxyAlkylation #CO2RadicalAnion pubs.acs.org/doi/10.1021/ja…

Congrats to Sojung Kim, our collaborator Jordan(Sigman Lab), our collaborators from Merck and former group members Justin & Yasuki on the publication of our work on understanding the enantioselectivity of our photomediated ring contraction in J. Am. Chem. Soc.! doi.org/10.1021/jacs.4…

Interrogation of Enantioselectivity in Photomediated Ring Contractions of Saturated Heterocycles | JACS Utah Chemistry UC Berkeley College of Chemistry Sarpong Group Total Synthesis and Methodology Highlights - Study of enantgioselective photomediated ring contraction of piperidines - pubs.acs.org/doi/10.1021/ja…

Congrats to Logan Bartholomew, Sojung Kim, Yusuke and collaborators Macroarc, Gilead Sciences, Merck on our indazole to benzimidazole conversion  onlinelibrary.wiley.com/doi/10.1002/an… coordinated with Leonori Lab  onlinelibrary.wiley.com/doi/10.1002/an…

Our study detailing indazole-to-benzimidazole phototransposition is out now in Angewandte Chemie together with related work from Leonori Lab! This has been a fun project to lead, and it’s been my privilege to work with this awesome team. Read below! (1/2) bit.ly/3Q1Uix9

Congrats to Logan Bartholomew & collaborators Lucas Karas (Sigman Lab) & Reilly & Charles Yeung (Merck) on the publication of our work on a cheminformatic analysis of core-atom transformations in pharmaceutically relevant heteroaromatics in J. Med. Chem. tinyurl.com/42re37pd

Phototransposition of Indaz (Richmond Sarpong and co-workers) Sarpong Group Logan Bartholomew Sojung Kim Macroarc Gilead Sciences Justin Jurczyk Charles Yeung Merck • onlinelibrary.wiley.com/doi/10.1002/an…