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Together with labs of Brian Liau and Philip Cole and many other collaborators, we are excited to share a new molecular glue story with many surprises. biorxiv.org/content/10.110…

Story 1: UM171 asymmetrically reprograms dimeric CRL3-KBTBD4 to degrade CoREST via HDAC1/2 with InsP6 as a second glue. Story (2): Cancer mutations of KBTBD4 found in medulloblastoma structurally, functionally, and mechanistically mimic UM171. biorxiv.org/content/10.110…

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…

Check out these amazing stories led by a fantastic group of collaborators in the labs of Brian Liau, ZhengLab, Philip Cole, @drpaulnorthcott, Ralph Mazitschek. This was such a fun project to work on and I’m glad our lab could help contribute! #molecularglues #quaternarycomplex

We are #hiring! We have an open #postdoctoral position in my group with the focus on structural biology #cryoEM and X-ray crystallography of new #E3 ligases as well as #molecularglue complexes. Rheinische Friedrich-Wilhelms-Universität Bonn isb_bonn nowak-lab.com Please RT!

If you liked the versatile TR-FRET methodology we reported in our cyclimid paper, check out our detailed STAR Protocols procedures. We are looking forward to seeing these approaches being (hopefully) broadly adapted! Ralph Mazitschek @drcmwoo & Saki Ichikawa sciencedirect.com/science/articl…

My mind immediately just went to this

Today in Science Magazine, together with my former colleagues at NIBR, we report the discovery and characterization of first molecular glue degraders of the WIZ transcription factor (TF) for fetal hemoglobin derepression and therapeutic consideration in Sickle Cell Disease. 1/10

Excited to see this out! Congrats to Forrest Hammel and the whole team!! Connor Payne Ralph Mazitschek Harvard Micro Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

How much to send me one? 👀

Today in nature we share our back-to-back stories with Ning Zheng revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6

Writeup of new nature articles from the Brian Liau Lab #chemtwitter news.harvard.edu/gazette/story/…

#severance