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Best advice I ever got for giving a talk, from my PhD supervisor, repeated to the lab today. (Dolled up by a TIDA UP state on the right.)

We made a little conservation of amino acids tool, combining Weblogo and ColabFold, which you can run in the browser with a single sequence. Since some major conservation servers are down. Hope it's useful! rodrigueslab.com/resources Rodrigues Lab Phill Stansfeld Sergey Ovchinnikov

Design a protein with 310 CoPilot

Google just launched Duet AI, and it might just overtake ChatGPT and Microsoft Copilot! Here are 5 mind-blowing features you don't want to miss:

Happy to have played a small part in this and we're still working on a few things to push this further. pnas.org/doi/10.1073/pn…

🔥🔥How does the LINE-1 retrotransposon jump around in the human genome? Super excited to present my postdoctoral work answering this published today nature together with twitterless Kathy Collins's lab and The Nogales Lab UC Berkeley nature.com/articles/s4158… A 🧵

The Shin lab is open for business on the 12th floor Children’s Research Institute at UT Southwestern!! Come chat about science, life in Dallas or anything😎

Macrocyclic Peptide Drugs From the Ground Up | Science | AAAS science.org/content/blog-p…

New paper from Alesi (@NicolaAlesi) et al. where the authors show that TFEB is the primary driver of renal disease and mTORC1 hyperactivation in Tuberous Sclerosis Complex (Lisa Henske). nature.com/articles/s4146…

Wrists sore from pipetting? Check out our preprint on “Surface Patterned Omniphobic Tiles (SPOTs): a versatile platform for scalable liquid handling”. biorxiv.org/content/10.110…

Fascinating!

Impressive! Achieved a speed of 1010 movies per hour on our Krios-K3 at ScopeEM ETH Zürich, thanks to the latest software upgrades. Now, EPU and Digital Micrograph communicate seamlessly. #cryoEM #gatan #TFS

I'm happy to share ColabFold-Pipeline-Toolkit, an easy recipe book put together to help streamline the use of ColabFold for newcomers without a computing background who want to perform high-throughput screens with ColabFold BATCH. 🧵 github.com/andyposbe/Cola…

Happy to share the publication of our paper in nature Conformational ensembles of the human intrinsically disordered proteome Work led by Giulio Tesei and Anna Ida🕊. I'll post more later, but for now here is a link: nature.com/articles/s4158… and a short movie about the work

🎉 We are thrilled to announce the release of the latest structure of the #cGAS complex in PDB as rcsb.org/structure/8OL1🌐✨Stay tuned for the full story in our upcoming paper, where we unveil the secrets behind cGAS transportation and its ultimate destiny. #Immunity

Check out our new publication on the fate of cGAS in cycling cells! nature.com/articles/s4158… It has been established that cGAS enters the nucleus and tethers to nucleosomes during mitosis. However, what is the ultimate fate of nuclear cGAS? 1/n

Check out the 2nd SnapShot of the ribosome biogenesis series featuring the 60S ribosomal subunit! This was a great collaboration w Ed Hurt & Roland Beckmann. Read the SnapShot & watch the animation w narration here: sciencedirect.com/science/articl…

I am thrilled to share the first preprint from my lab at Mizzou Biochemistry! My colleague C. Keith Cassidy and I determined the structure of apoB100 from human low-density lipoprotein (LDL). This protein is wild! biorxiv.org/content/10.110…

Defining the EM-signature of successful cell-transfection biorxiv.org/cgi/content/sh… #biorxiv_cellbio

Thrilled to present the structure of mTORC1 on membrane. We are at an exciting time of using SPA to resolve high-resolution structures of complexes that land on the surface of membranes! Looking forward to seeing what can be done for this research frontier in the near future!