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Online Now: Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity dlvr.it/Sph47f

Online Now: Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy dlvr.it/SphbJm

We find cholesterol distributes unevenly among intratumoral cell populations. Intratumoral T cells have cholesterol deficiency due to oxysterol-mediated metabolic rewiring. Normalizing cholesterol levels improves CAR-T cell therapy. Cancer Cell link: authors.elsevier.com/a/1h8lB5TA51da…

Interesting finding of amino acid restriction and cGAS modification.

Our newly published review "Charging CAR by electrostatic power" illuminates the critical role of electrostatic interactions in enhancing CAR-T cell therapy. Discoveries point to future strategies centered on charge-based interactions. doi.org/10.1111/imr.13…

We are excited to present a work of TCR condensation published in PNAS. CD3e ionically interacts with Lck to form condensates that can be dissolved by pCD3e-Csk interaction. Title: Self-programmed dynamics of T cell receptor condensation | PNAS pnas.org/doi/10.1073/pn…

Excited to share our 1st TCR-T therapy study with Drs. Haopeng Wang and Jizhong Lou, published in Cell Chemical Biology: Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity! cell.com/cell-chemical-…

We are happy to publish a perspective Nature Rev Immunol, focusing on a charge-based signaling motif BRS. Being widely present in immunoreceptors and other membrane proteins, BRS can regulate many aspects of immune responses. nature.com/articles/s4157…

Glad to share our new publication Immunity , reporting a new E-CAR that can form mature immunological synapse through phase separation. Paper link: authors.elsevier.com/a/1kATc_OR%7Ey…

Really glad that our paper has been highlighted. Modified CARs Self-Condense to Form Optimal Immunological Synapses aacrjournals.org/cdnews/news/19…

Happy Chinese New Year!

Thrilled to share a new example of Basic residue Rich Sequence signaling, published at CELL. Congratulations to Haopeng Wang, Dario Vignali and other collaborators. cell.com/cell/fulltext/…