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First of a series of papers from the @NCIHTAN is out in nature this morning. Tumour evolution and microenvironment interactions in 2D and 3D space nature.com/articles/s4158…

Ovarian cancer-derived IL-4 promotes immunotherapy resistance: Cell cell.com/cell/fulltext/… Icahn Genomics Institute Icahn School of Medicine at Mount Sinai Brown Lab, Baccarini lab Miriam Merad, MD, PhD Peter Sorger @SantagataLab Dmitriy Zamarin MD PhD Chiara Falcomatà Jia-Ren Lin Nelson LaMarche .

New study in nature today: Clinical functional proteomics of intercellular signalling in #PancreaticCancer nature.com/articles/s4158… Absolutely stunning amount of cross species spatially and temporally resolved proteomics data in pancreatic cancer. What a resource!

Very excited to share our latest work on the uncoupling of epithelial regeneration and tumorigenesis in the gut! nature.com/articles/s4158…

So excited to share our new paper out in nature led by the fabulous Anais Elewaut and Guillem Estivill providing mechanistic insights into anti-tumor immunity and why it may fail in so many patients! Sky-torial on Anna Obenauf.bsky.social rdcu.be/d1F7s

Several years in the making (and aging), Xueqian Zhuang 's study on aging is out today nature. She finds, surprisingly, that aging suppresses tumorigenesis and stemness in the lung by promoting a functional iron insufficiency in the alveolar epithelium. nature.com/articles/s4158…

First lab tweet! Sharing new papers: PRINT Using Perturb-map, we show how ovarian tumors resist immunotherapy loom.ly/eHXDm4w PREPRINT Developed new technology to easily generate cell-targeted LNP-RNA Sandro Santagata Joshua Brody, MD Yizhou Dong

Sandro Santagata Joshua Brody, MD Yizhou Dong More details on 'Bispecific antibody targeting of lipid nanoparticles' in the bioRxiv here >>> biorxiv.org/content/10.110…

1/ Excited to see moscot-tools.org published in nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at nature.com/articles/s4158…

HUGE congratulations to Linghua Wang, MD, PhD & team for her latest Cancer Cell study Integrative analyses of over 14 million cells from 10 cancer types across 7 spatial transcriptomics and proteomics platforms identifies four distinct spatial CAF subtypes conserved across cancer types

🤩Super excited our branched #PancreaticCancer #Organoids to capture tumour heterogeneity made it on the cover of Nature Biomedical Engineering 🙏🏼nature.com/natbiomedeng/v… TU München VomLaborInDiePraxis @TUMKlinikum Aristeidis Papargyriou Reichert Lab

Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with OmicVision Andreas Mund Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!