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A2: Future HER2 evaluation may include RNA-based methods such as RT-qPCR #HER2low #PathTwitter #BreastPath

A4: Recent abstract from AACR about proficiency assessment of HER2-low scoring using different assays aacrjournals.org/cancerres/arti… #HER2low #PathTwitter #BreastPath

A4: Another comparison of HercepTest and Pathway 4B5: more tumors were overscored as IHC 2 + by HercepTest link.springer.com/article/10.100… #HER2low #PathTwitter #BreastPath

A4. We did a survey study to identify the most commonly used antibodies, 4B5 came on top, which is the only FDA approved companion diagnostic indicated to identify HER2-low status in patients with metastatic breast cancer. #HER2low #PathTwitter #BreastPath

Q5: How do preanalytic and analytic variables impact the quality of HER2 testing? #HER2low #PathTwitter #BreastPath Dr. Bui Pathologist🌼 Swikrity U Baskota,MD, FCAP MAMATHA CHIVUKULA,MD,FASCP Thaer

Q4: prolonged cold ischemic time can reduce HER2 IHC staining #her2low

Q4: beware of crush and edge artifacts scoring HER2 by IHC #her2low

Q5: #her2low thin sections may result in false negative results of HER2

#her2low 4B5

#HER2low Daisy trail results presented at SABCS2022 and investigators found T-Dxd has clinically meaningful activity in HER2 positive, HER2low and HER2 zero advanced breast cancer,#breast path

#her2low micro- papillary carcinoma retraction can be over scored by HER2 IHC

ASCP Dr. Bui Pathologist🌼 MAMATHA CHIVUKULA,MD,FASCP Thaer A7: Since interobserver variability still occurs, QIA offers an objective and reproducible scoring method #HER2low #PathTwitter #BreastPath

#her2low sTudies of QIA have shown reduced equivocal cases of HER2

There are differences in QIA approach. Some analyze areas of interest. Some analyze the whole tumor area. Some algorithm trained to adjust the HER2 FISH data.

#her2low CAP guidelines on QIA of HER2 IHC were published in 2019

Thank you ; muchas Gracias 🙏🏽to all Medical Laboratory Professionals Rex Famitangco,MS, MASCP, MLS(ASCP)cm QLCcm ASCP #National lab week 🔬🧪🧫

Vamos Carlos Almendárez Alcaraz Wimbledon 🏆👏🏼🎉🎊at 20 yrs

Coco Gauff❤️US Open Tennis

Interesting data ..

Immensely Proud of @carley, Anna Marie, MD, former fellow UPMC Magee loves a good parody women’s Hospital of UPMC 👏🏼 thelibrarydistrict.org/blogs/post/dr-…