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Excited to share our preprint led by Chong Li from our group, in collaboration with Jonas Simon Fleck Treutlein lab! We developed CRISPR-human organoids-scRNA-seq (CHOOSE) system to explore developmental defects caused by autism gene perturbations. biorxiv.org/content/10.110…

1/7 📢Happy to share the preprint of our latest study "Integrated transcriptome and proteome analysis in human brain organoids reveals translational regulation of ribosomal proteins" led by Jaydeep Sidhaye and @PhilippTrepte biorxiv.org/content/10.110…

📢Preprint alert! Here's our latest story, led by Catarina Martins Costa Brain organoid morphogenesis can be driven by exogenous ECM (Matrigel), or self-sustained by endogenous ECM production. Late development is mostly independent of the initial ECM source tinyurl.com/5n6n9ss3 🧵1/7

Thanks for organizing such a wonderful meeting! Great science and discussions!

Does the human brain have an Achilles heel that ultimately leads to #Autism? With Treutlein lab (ETH Zurich) & MedUni Wien, The Knoblich Lab researchers led by Chong Li develop CHOOSE, a revolutionizing system to test multiple disease-related mutations in a single #brain #organoid.

📢 We’re live at the The EMBO Journal! 🌐 tinyurl.com/39xdttna Human telencephalic organoids cultured in the absence of Matrigel endogenously produce and self-organize the extracellular matrix, without affecting programs of neuronal differentiation. Led by Catarina Martins Costa 👩‍🔬 🧵 1/5

We are excited to share our latest work on developing a model of the human dopaminergic system with functional dopaminergic innervation, which we use to study Parkinson’s cell therapy as well as the reward system, published today in Nature Methods (nature.com/articles/s4159…).

🎇Big news! Prof Juergen Knoblich IMBA imbavienna.bsky.social Austrian Academy of Sciences MedUni Wien joins #TeamIHB as its new Head. Bringing extensive leadership experience, he is also a pioneer in #organoids biology. His lab was 1st to develop an organoid model for a human brain disorder. Welcome The Knoblich Lab!

Extremely grateful for the support of the The Knoblich Lab and IMBA imbavienna.bsky.social during this postdoc journey, where I met amazing scientists from around the world! Excited to start my own group soon at CIBR to continue exploring some of the most fascinating areas of human brain research!