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1/ Why does giant cell arteritis (GCA) have a predilection for the temporal artery? There are many medium/large-sized vessels in the body, and yet GCA hones in on early branches of the aorta. As you might guess, I think the answer is pretty cool...

Voices of ID: Our “Side Hustle” by Erin McCreary 🆓 Freely Available 🔗 bit.ly/3u4pa8g

The promise of CAR-T therapy in severe SLE and autoimmune disease #ACR23 with Dr Georg Schett. Excited to see our early work on rituximab in SLE cited URMC Allergy, Immunology, Rheumatology URMC Department of Medicine #URochesterResearch #AdvancesHappenHere

B Cell–Directed Therapy in Autoimmunity Annual Reviews Jen Anolik doi.org/10.1146/annure…

Wouldn’t it be great to have a streamlined process for adding a new disease indication to an existing drug’s label? When we consider drugs that have been on the market for, say, a decade or more, with a clear safety record and no significant adverse signals, it's time to rethink

One of the key findings about the GLP-1 drugs "We have established the [brain-immune network] anti-inflammatory effect of GLP1RAs independently of their metabolic benefits." Succinct summary of recent Cell Metabolism report nature.com/articles/s4157… sciencedirect.com/science/articl…

Identifying immune signatures of common exposures through co-occurrence of T-cell receptors in tens of thousands of donors biorxiv.org/content/10.110…

Excited to share our new review on PR3-ANCA associated #vasculitis, part of a series now in The Lancet Rheumatology ahead of Vasculitis Workshop Barcelona #VasculitisBCN2024. Great team effort led by Sam Falde, MD, Profs Specks and Lambrecht, with Henry Tazelaar, Erin K O'Brien MD, Max Konig. authors.elsevier.com/c/1isC89UBHvrs…

Discovering tens of thousands of new antibiotics from #AI of proteins of extinct animals! nature.com/articles/s4155… @NatBME @delafuenteupenn Penn Medicine Penn Bioengineering Marcelo Torres Jackie Peng

Use of LLM #AI to improve efficiency, accuracy, reliability, and reduce costs for screening individuals that fit criteria a clinical trial (performance as good or better than human "study staff") ai.nejm.org/doi/full/10.10… Ozan Unlu Mass General Brigham NEJM AI

🚨Scoop: A behind-the-scenes look at the bird flu outbreak shows the US hasn't fixed a key failing from covid -- getting people tests. Only 45 people tested over the past 3 months. "We're flying blind," said Jennifer Nuzzo, DrPH. Mine KFF Health News kffhealthnews.org/news/article/c…

Cell therapy is in the middle of a huge shift... ...and everyone from small biotechs to big pharma want in on the next big thing: autoimmune disorders Here's how I think this goes down: First, I charted the programs of 37 companies in this space, segmented by cell source and

We've already seen remarkable results for lupus and other autoimmune diseases with CD19 B cell depletion therapy. Now add IgG4 related disease (which has no treatment) in a new randomized trial NEJM nejm.org/doi/full/10.10…

Dr. Ralf Thiele discusses the clinical utility of #ultrasound in #gout #CPPD & #BCP #ACR24 #RhMSUS #crystallinearthritis #advancedultrasound #POCUS

#urmc #urmedicine

Targeting autoreactive B-cells in lupus is a successful treatment, but can cause immunosuppression. Jin Liu’s study details a new T-cell therapy that can selectively eliminate certain B cells in patients with lupus, while avoiding complete immunosuppression. #ACR24

In a session on new therapies for autoimmune diseases, Max Konig discusses his research with CAR-T cell treatment, showing how specific immune cells can be targeted to treat conditions such as lupus without compromising the immune system. #ACR24

We are so thrilled to announce Jennifer Anolik, MD, PhD, has agreed to serve as Chief of Allergy/Immunology and Rheumatology (AIR). Dr. Anolik is a Professor of Medicine and Associate Chair for Research in the Department of Medicine. Excited for our department UR Medicine

WHY DOES THE EPIGENETIC CLOCK TICK? While money has been poured into developing therapies to reverse the epigenetic clock (Altos Labs 🤑), why the epigenome changes with age at all is unclear. In Nature Aging today, we suggest a potential driver: somatic mutations.

LLMs are recursively deep software, but shallow causal structures in assembly space; human minds are recursively deep causal structures in assembly space, and our “software interface” is shallow. We can easily trick ourselves by anthropomorphizing a reality that is not there,