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#OriginalResearch: DSc-2mRNA treatment exhibits a therapeutic potential in the treatment of ARVC on animal models, establishing a foundation for prospective clinical applications. #AHAJournals Yan Zou Jennifer Wong Yuxiang Dai ahajrnls.org/44bwcYw

#OnMyMind: A new clinical classification for aortic stenosis—stable, progressive, and acute valve syndromes—captures distinct presentation patterns with prognostic value. Recognizing acute presentations ... #AHAJournals Philippe Genereux Vanderbilt Structural Heart & Valve Center Philippe Pibarot ahajrnls.org/4mUVGkf

#ResearchLetter Cardiomyocyte-specific loss of METTL3 or METTL14 disrupts m6A methylation of sarcomeric transcripts, impairs sarcomere maturation, and causes lethal pediatric DCM in mice. A key post-tran... #AHAJournals Vidu Garg Deqiang Li(DQ) Jihyun Jang ahajrnls.org/4e3dRAs

Considerations of Intraoperative Transesophageal Echocardiography During Adult Cardiac Surgery #AHAJournals ahajournals.org/doi/10.1161/CI…

📢 Expedited Review for #ESCCongress 2025! CircImaging invites authors with accepted ESC presentations to submit manuscripts for rapid review. Initial decisions within 10 days! Submit by June 23 👉 ahajournals.org/circimaging/ex… #CardioTwitter #CardioImaging Kaz Negishi@Cardiologist/ Heart Mafia

📢Expedited Review for #ESCCongress 2025! Circ: Heart Failure invites authors with accepted ESC presentations to submit manuscripts for rapid review. 📍Initial decisions within 10 days! 📝Submit by June 23 🔗Learn More: ahajournals.org/circheartfailu… #AHAJournals Nancy Sweitzer MDPhD James Fang

Real-world evidence is stepping up to fill the gaps left by RCTs. With methods like external control arms & BenchExCal, we can benchmark, expand & calibrate data to answer urgent clinical questions—rigorously. ahajournals.org/doi/full/10.11…

Too many patients with severe aortic stenosis still go untreated. The DETECT-AS trial shows a simple electronic nudge to providers can boost valve replacement rates—especially in older adults. Scalable. Smart. Life-saving. ahajournals.org/doi/full/10.11…

A first-in-human trial of XXB750, a long-acting NPR1 agonist, shows promising BP-lowering effects and sustained cGMP activation after a single dose. Once-monthly natriuretic peptide–based therapy for CVD? ahajournals.org/doi/full/10.11…

Regularly monitoring heart peptide (natriuretic peptides) levels should become standard practice. Waiting for symptoms to manifest misses the critical window for early intervention. ahajournals.org/doi/full/10.11…

How can we harness cardiac biomarkers to guide treatment decision among individuals with asymptomatic severe aortic stenosis? ahajournals.org/doi/full/10.11…

How can the win ratio be effectively used and communicated in cardiovascular clinical trials? ahajournals.org/doi/full/10.11…

TET2 mutant clonal hematopoiesis promotes heart failure with preserved ejection fraction via proinflammatory pathways ambarish, Amanda Tong, Chung Lab, UT Southwestern Medical Center @mattsegar Daniel Daou Wenhuo Hu Naveen Premnath ahajournals.org/doi/full/10.11…

A Systematic Review of “Food Is Medicine” Randomized Controlled Trials for Noncommunicable Disease in the United States #AHAJournals ahajournals.org/doi/10.1161/CI…

Co-published by ACP and AHA Science #AHAJournals, Annals of Internal Medicine: Clinical Cases is a peer-reviewed, open access journal that publishes #casereports, case series, and image/video cases across the spectrum of medicine. Learn more and submit to AIMCC today at ahajrnls.org/3GBOSW0

RhoA inactivation via the TRPV4-RhoA-RhoGDI1 axis reduces vascular contraction and remodeling, offering a potential strategy for hypertension treatment ahajournals.org/doi/10.1161/CI…

An evidence-based Plakophilin-2 specific longitudinal screening algorithm for arrhythmogenic right ventricular cardiomyopathy may improve patient care and efficiency of clinical resource allocation Pim van der Harst Sing-Chien Yap J.Peter van Tintelen ahajournals.org/doi/10.1161/CI…

#ICYMI: Lp(a) and vascular disease types across ancestries #AHAJournals

ICYMI: Splenic Marginal Zone Macrophages and MI @MAIwusl, Sumanth Prabhu, MD, WashU Medicine Cardiovascular Division, WashU Medicine Department of Medicine @ssbansal_pshvi

#ICYMI: PGI2–IFN axis involves in spleen EMH after MI