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Excited to get this preprint out! ByeTAC: Bypassing an E3 Ligase for Targeted Protein Degradation biorxiv.org/content/10.110…

Really late sharing this, but super excited for my first paper from Trader Lab! 🧫 Check out the discovery of TCL-1 a new ligand for the proteasome subunit Rpn-13. Can’t wait for many more to come! doi.org/10.1016/j.bmcl…

Super excited to be selected for the SPPS PhD Student Spotlight! Check it out here 🧪 UCI School of Pharmacy & Pharmaceutical Sciences Trader Lab PhD Student Spotlight: Research Opportunities Through the Trader Lab Brought Cody Loy to UC Irvine from Purdue University  pharmsci.uci.edu/2024/01/25/phd…

Congrats Eslam and Thanks @ACS_DivBioChem !!!

Had an amazing experience Janelia Conferences and got to learn some really exciting chemical biology! Thank you for the opportunity to share some of my recent work and meet some excellent scientists 🧫🧪

Everybody look out, I’ve advanced to PhD candidate status!🍾 😎

Had an amazing experience at my first Bioorganic Chemistry GRC! From the exciting talks to making some incredible friendships, I can’t wait to go back to science summer camp. 🧪🏕️ Oh, and winning an outstanding poster award wasn’t too bad either!

Congrats Cody Loy on your recent review on the proteasome's primed substrate channel! doi.org/10.3390/molecu…

Congrats Cody Loy on your RSC ChemBio paper on a caged luciferin probe for the immunoproteasome! doi.org/10.1039/D4CB00…

Always fun developing new tools to monitor immunoproteasome activity! Check out our latest probe paper 🔭🧪

I’m so excited to welcome MrTAC to the world of targeted protein degradation! We created a chemical inducer of arginine methylation that can be used to degrade proteins in lysosomes 💊 So grateful for everyone involved in this project 🥳🥳 nature.com/articles/s4158…

Check out our recent work- Synthesis and Application of a Versatile Immunoproteasome Activity Probe …mistry-europe.onlinelibrary.wiley.com/doi/epdf/10.10… now in ChemBioChem Big thanks and congrats to Cody Cody Loy and Trader Lab for pushing this through #chemicalprobe #proteasome #ABPP

UCI's Albrecht and Trader labs have developed a groundbreaking protein degradation tool called MrTAC (Methylarginine Targeting Chimera) which offers a game-changing method to eliminate disease-causing proteins within minutes. bit.ly/4fNMf2l

Honored to have our image on the cover of this month’s issue Nature Chemical Biology featuring the MrTAC paper (linked below)! 🔬🧫

Immunoproteasome as a Target for Prodrugs | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

So excited that ByeTAC is now out!! Major congrats to Cody Loy and Trader Lab 🥳🥳 pubs.acs.org/doi/10.1021/ac…

ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation | Journal of Medicinal Chemistry pubs.acs.org/doi/10.1021/ac…

A UCI-led research team analyzed the potential of a protein degradation mechanism as a resolution to a long-standing issue in the world of medicine — how to treat disease without damaging nearby healthy cells. Read more: pharmsci.uci.edu/2025/04/30/uc-…