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Great preprint >> Opioid receptors and other human GPCRs functioning in yeast biosensor strains. A previously impossible feat achieved by metabolic engineering the yeast so that they make and use cholesterol in their membranes (like human cells do). 👏👏biorxiv.org/content/10.110…

I'm exited to share a new preprint from the lab, the culmination of Momo Sae-Lee's PhD, with major contributions from @computingCaitie & Eric Verbeke, in which we mapped the proteome & interactome of the simplest primary human cell type, red blood cells: biorxiv.org/content/10.110…

Even after 1 billion years of evolution, humans and a tiny aquatic organism still share this key organelle that could help reveal clues about birth defects. cns.utexas.edu/news/ancient-c… Edward Marcotte Colleen Mulvihill @computingCaitie

Congrats to Colleen Mulvihill! Our latest manuscript on the humanization of yeast & GPCRs! Wonderful collaboration with Edward Marcotte & @VincentjjMartin Molecular Biosciences! nature.com/articles/s4146…

New “Review” from Kachroo Lab “Humanized yeast to model human biology, disease and evolution” journals.biologists.com/dmm/article/15…

Work by Simon dOelsnitz, Alper Laboratory, Andy Ellington & colleagues evolves a general transcription factor into specific biosensors for various alkaloids, enabling streamlined production of tetrahydropapaverine. Free to read link at rdcu.be/cRb3T

Listening to the amazing @computingCaitie's PhD defense. She wears her science proudly! (Wait--is that her #PS36 poster?)

Mutational effects in Omicron BA.1 & BA.2. Kamyab Javanmardi, Ph.D. ⚛️ Jimmy Gollihar Ilya Finkelstein examine antigenicity, expression & hACE2 affinity across #Omicron BA.1 & BA.2 mutations, revealing cryptic cross-domain interactions that enhance Ab escape & stabilize Spike cell.com/cell-host-micr…

Our preprint on human cannabinoid receptor expression and compound screening in yeast is out! biorxiv.org/content/10.110…