Go IL-2!!

In scRNA-seq analysis, "overcorrection" of batch effects is a frequent cause for loss of important biological variability. Using prior celltype knowledge is a powerful way to limit overcorrection and should be more common practice. Sharing new preprint! biorxiv.org/content/10.110…

Happy to share the peer-reviewed version!⛺️ Now including additional analyses of i) impact of celltype composition imbalance across samples, and ii) noise in celltype labels on integration performance. Thanks to reviewers & editor for constructive feedback nature.com/articles/s4146…

In most biomedical studies that use single-cell omics, the biological replication unit is the whole sample/tissue and not the cell More important than highlighting the total number of cells is to highlight the number of independent samples (each having at least 100-1000 cells)

💡NEW study from Barras et al. in melanoma patients shows T cell-myeloid cellular networks mediate response to adoptive T cell therapy, in Science Immunology #CancerResearch #cancerday George Coukos Denada Dangaj Ludwig Cancer Université de Lausanne CHUV / Centre hospitalier universitaire vaudois ➡️news.unil.ch/display/170712…

Memory genes are enriched in CAR T cells that persist and control tumors in patients. But which transcription factors drive beneficial memory programs? We answer this in our lab’s first paper in nature led by Alex Doan Kat Mueller, PhD Andy Chen. 1/ nature.com/articles/s4158…

We are thrilled that our study on PGE2-mediated impairment of TCF1+ stem-like CD8+ T cell responses in cancer, with (twitterless) Sebastian Lacher as first author, is now published nature! 👇 a short 🧵 below! nature.com/articles/s4158…

Proud to share the results of our study on the effect of prostaglandin E2 on T cells, which was just published in Nature in which we discovered a new role for PGE2 in inhibiting interleukin-2 (IL-2) sensing and signalling in tumor-reactive T cells nature.com/articles/s4158…

The results of our study on the effect of prostaglandin E2 on T cells - Matteo Morotti (Ludwig Cancer / @chuvlausanne) oncodaily.com/56410.html Alizee Grimm Denada Dangaj Institute of Molecular Immunology Jan Böttcher HoLab @vannini_lab Jesus Corria-Osorio The Conrad Lab Helen Carrasco Hope #oncodaily #oncology #cancer

Thanks!

Previously unseen details of human brain structure revealed. Featured image: a single neuron with ~5,600 of the nerve fibers that connect to it. I feel overwhelming awe at nature's complexity and order. nih.gov/news-events/ni…

Happy to share an exciting work from the lab in collaboration with François Kuonen and team! Many studies have established the impact of wounding on early steps of tumor initiation. However, little is known about the effect of wounding on progression of established human tumors.

The under-appreciated non-linear effects of transcription factors dosing on cell fate. Fascinating work presented by @BartDeplancke at today's SIB single-cell focus group meeting. Exciting research directions ahead. biorxiv.org/content/10.110…

Cellular architecture is a predeterminant of early TCR signaling and subsequent cell fate decisions of individual naïve T cells in response to antigen Science Magazine Ben Hale Berend Snijder science.org/doi/10.1126/sc…

"The maximal lifespan [of people and 347 mammalian species] is strongly associated with an epigenetic signature that is largely independent of sex, body mass, calorie restriction, or other lifestyle factors" Science Advances science.org/doi/full/10.11… Prof Steve Horvath and colleagues

Big thanks to Katharine Block & Steve Jameson Jameson Hogquist labs for this brilliant and thoughtful commentary on our recent Immunity paper. You’ve summarized it better than I could! cell.com/immunity/abstr…

#ID2024 Immunology Day in Geneva is happening now! We're enjoying great presentations from biotech & UNIGE_en research groups, including brilliant keynote speaker Prof George Coukos 🙏 George Coukos Ludwig Cancer Oncology UNIL CHUV #Vaccines #Immunotherapy Stay tuned for more!