New review from Kaitlyn Dayne Beccano Steph Cragg & Wade-Martins Lab explores the question (& evidence) of whether there is impaired dopamine release in #Parkinsons before there is any cell loss academic.oup.com/brain/advance-…

Dopamine release deficits in #Parkinsons there is actually dysfunction or dysregulation of axonal dopamine release before cell loss. Blows your mind right, think about it, and read this Brain and it will make sense. academic.oup.com/brain/advance-…

Cramb et al. review the evidence for dopamine release deficits prior to neurodegeneration in Parkinson’s disease, and highlight mechanisms by which these deficits can occur. bit.ly/3GOTw2d

Check out new work from our lab exploring mitochondrial dysfunction in Parkinson's disease. Congrats to all authors, especially Marta Madureira on her first first author paper! 🥳

Our new paper is out in Human Molecular Genetics! We show impaired mitophagy in LRRK2 R1441C iPSC-derived dopaminergic neurons from people with Parkinson's and primary cortical neurons. academic.oup.com/hmg/article-ab… Some of Matt's cortical cultures even made the front cover!

SEPT 15 2023 Issue: academic.oup.com/hmg/issue/32/18 Cover: Mitochondrial dysfunction and mitophagy defects in LRRK2-R1441C Parkinson’s disease models doi.org/10.1093/hmg/dd…

Delighted to share our paper Nature Communications. We show that C9orf72-#ALS iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9. Special thanks to all the amazing people from Oxford MND Research who contributed! Nuffield Department of Clinical Neurosciences Kavli Institute for Nanoscience Discovery, Oxford nature.com/articles/s4146…

Thank you to @CanUKFoundation The Maple Leaf Trust CanadianUK Robert_Fry 🇨🇦 and Ralph Goodale for celebrating our scholars with us this evening. We wish you all the best with your exciting work.

Happy to share my 2nd iPSC paper from my PhD studies with Wade-Martins Lab at nature.com/articles/s4138…! We showed that depleting tau in human iPSC-derived neurons is protective against Abeta. It was a collaborative effort, extremely thankful to the team. #research #Alzheimer

SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides biorxiv.org/cgi/content/sh… #biorxiv_neursci

Our latest preprint is out! We developed ASOs targeting human SARM1, and report exciting mechanistic insights showing that neurotoxicity and mitochondrial dysfunction are reversible, even hours after SARM1 activation! In human neurons! Key implications for SARM1 therapies #SARM1

Very excited to share that our preprint is online now! Andrea Loreto and I show that SARM1 neurotoxicity is reversible and can be prevented in human neurons using ASOs. Massive thanks to the whole team! Wade-Martins Lab Michael Coleman Kavli Institute for Nanoscience Discovery, Oxford biorxiv.org/cgi/content/sh…

Delighted that Quyen B Do paper “Early deficits in an in vitro striatal microcircuit model carrying the #Parkinson's GBA-N370S mutation” is now published pubmed.ncbi.nlm.nih.gov/38609392/ Nora BV Department of Physiology Anatomy & Genetics (DPAG) Kavli Institute for Nanoscience Discovery, Oxford DPAG Athena Swan

🚨new preprint alert!🚨 very excited to share the story of my PhD work :) including: development of excitatory-inhibitory circuits, lineage labelling, in vivo patching and re-thinking blanket inhibition. biorxiv.org/content/10.110… See below for a quick summary! [1/17]

Anxa1+ dopamine neuron vulnerability defines prodromal Parkinson's disease bradykinesia and procedural motor learning impairment biorxiv.org/cgi/content/sh… #biorxiv_neursci

Check out ASAPs team Craggs latest preprint on the selective vulnerability of Anxa1+ dopamine neurons in PD! ASAP Team Cragg @meletislab Wade-Martins Lab