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Congratulations to Lei.Per on publishing this story in Molecular Therapy! We show that CAR T cells generate humoral immune responses in patients and we engineer them to secrete antibody-cleaving enzymes.

Congratulations to our student Dr. Christopher Bourne (he/him) on receiving this transitional fellowship. Well deserved we are all very proud of you! 🎉🎉

Congratulations to Pedro C Silberman, PhD, MEng on winning First Place at the Weill Cornell GSMS 3 minute thesis contest!

Excited to share my work from Scheinberg Lab lab out today in Nature Chemical Biology where we develop CAR-T cells that produce small molecule drugs at the tumor site. This is an exciting step forward in the utilization of engineered cells for drug delivery! nature.com/articles/s4158…

2.5 years of revision and over 5 years of collaborative work, CONGRATULATIONS to Thomas Gardner , Scheinberg Lab and all others who contributed to this manuscript 🎉🎉🥳🥳. This novel platform will change adoptive T cell therapy. My thesis work will build on this. More info 👇🏾👇🏾👇🏾

In our Scheinberg Lab paper we demonstrate that T cells can be engineered to release small molecule chemotherapies at the tumor site. We do this using bacterial enzymes. In the current paper, we use immunodeficient mouse models as a human proof of concept.

One critique of this platform that uses bacterial enzymes is that host immune responses will reject it. In my thesis work, I adapt this project in fully immunocompetent mouse models. We've had very promising efficacy results so far!

Stay tuned! This is a massive collaboration across multiple labs and disciplines at @sloan_kettering Weill Cornell GSMS Weill Cornell Medicine !!

Congratulations Thomas Gardner and our collaborators in the Tan lab for this awesome work! We show how adoptive T cell therapies like CAR T cells can be used to deliver small-molecule drugs to tumors. This is the first manuscript of many to come on this project.

ROCK STAR! Check out this article on our grad student Dr. Christopher Bourne (he/him) on his recent Sawyers fellowship award! A Young Scientist Earns MSK Fellowship: Here’s When He Had His ‘Aha’ Moment mskcc.org/news/young-sci…

Congratulations to former fellow Martin Klatt on this groundbreaking publication! Using Mass Spec, we identify a novel target, NDC80, and target it with TCR mimic antibodies.

Congratulations to Dr. Heather Jones on her successful thesis defense today!! She delivered an outstanding presentation. Be on the lookout for her upcoming study on TCR cross-reactivity.

Fantastic talk by Emma Reynaud wrapping up months of amazing work imaging CAR T cells in action diagnosing & treating cancers Memorial Sloan Kettering Cancer Center Simone Krebs Laboratory Scheinberg Lab Jan Jacob Schuringa Larsonlab #theranostics

Welcome to the lab and to Twitter Stephanie! We are excited to see the awesome work you will do.

Congratulations to Dr. Bourne (Dr. Christopher Bourne (he/him)) my younger big brother for an incredible thesis today! You’re truly an inspirational person in and out of the lab. A phenomenal scientist, dedicated DEI activist, and a monster of a cyclist! UPenn is incredibly lucky to have you!

Congratulations to my husband, Dr. Bourne!! Dr. Christopher Bourne (he/him) I'm so proud of you. It's an honor to be along for the ride.

I recently gave a short talk at the #CIMT2023 conference in front of 300+ people. Though nervous, I overcame my fears to present to an international audience for the first time. It was so rewarding to engage in meaningful conversations about my research and to hear others’ work.

A huge congratulations to Dr. Christopher Bourne (he/him) on his recent thesis defense! You've done phenomenal work, and we look forward to your future success. You will be great missed!