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Two mutations convert a natural fatty acyl-CoA synthetase from nonluminescent fruit fly into a luciferase (“FruitFire”) capable of generating light with the synthetic luciferin CycLuc2 in vivo (in the mouse brain). Not a de novo luciferase but shows how new functions can be

Researchers have developed Opto-RhoGEFs, an optimised optogenetic toolbox to reversibly control Rho GTPase activity, advancing the ability to manipulate the barrier between endothelial cells. elifesciences.org/articles/84364…

New jGCaMP8 viruses available Addgene !! Get 'em while they're hot! #GCaMP #neuroscience #calcium

Excited to introduce our optimized green and red fluorescent dopamine (DA) GRAB sensors #GRABSensors #dopamine Great collaboration with Mitsuko Uchida‘s group at Harvard University, Yingjie Zhu’s group at SIAT, John Williams’ group and Marina Wolf’s group at OHSU.

Nature research paper: A bioelectrical phase transition patterns the first vertebrate heartbeats go.nature.com/3RDdUcT

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Physics to Pierre Agostini, Ferenc Krausz and Anne L’Huillier “for experimental methods that generate attosecond pulses of light for the study of electron dynamics in matter.”

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2023 #NobelPrize in Chemistry to Moungi G. Bawendi, Louis E. Brus and Alexei I. Ekimov “for the discovery and synthesis of quantum dots.”

I realize that almost all of my followers are GCaMPers, but another reminder that we're trying to work on climate stuff too. Would love to co-submit something on C capture, T tolerance, biofuel, plastic, anything.

Want to know what the burning questions are in brain energy metabolism research? Read vignettes on #lactate #citrate #glycogen #aspartateshuttle #spreading depression #ketones and more from experts in the field. doi.org/10.1111/jnc.16…

Here's a nice summary of our recent preprint on how to do 2P voltage imaging with FRET-opsin voltage indicators. It turns out you need to populate a photocycle intermediate state to see voltage sensitivity!

Online now! AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells by Lars Hellweg, Kai Johnsson, Philipp Leippe, and colleagues at EPFL Max Planck Institute for Medical Research CeMM dlvr.it/T7Vyjf #chembiol

The first Microtutor interactive virtual imaging course is now live on the Global BioImaging training platform! Learn fundamental principles that are critical to rigorous fluorescence microscopy experiment design. Free & open to all! Funded by CZI Science. microtutor.globalbioimaging.org

First paper from the lab biorxiv.org/content/10.110…! Long story short: Emine Zeynep Ulutas, Amartya Pradhan, Dorothy Koveal and I developed a method using injectable nanoparticles to turn mice into…constellations in motion.

Looking for a fluorescent biosensor and don’t know where to start? Want a comprehensive overview of the field? Check out our new review in Chemical Reviews online now as an ASAP article! From co-first authors Dr. Anneliese 💖💜💙 @AyseZSahan Yanghao Zhong doi.org/10.1021/acs.ch…

Check out our minireview on DA sensors and how they benefited neuroscience: authors.elsevier.com/a/1k6hE8MqMiqW… Great teamwork of my students and postdoc Xuehan Zacharoula and Paul

Online now on biorxiv: our new voltage indicator engineered for red 2P optical recordings, 2Photron. Only possible thanks to great collaborators Eric Schreiter,Dieudonné lab @[email protected],Kaspar Podgorski, and others! biorxiv.org/content/10.110…

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time

Hear from PAGER’s co-creators, Nick Kalogriopoulos and Reika Tei in this Stanford news story from Taylor Kubota: Tool that enhances control of cellular activity could expand biological and medical frontiers news.stanford.edu/stories/2024/1…

Check out our new paper in Nature Biotechnology sharing our latest kinase activity reporters! Led by former postdoc Michelle Frei, these reporters are based on HaloTag rather than an FP, for far-red imaging and superresolution! nature.com/articles/s4158…