Here it is, our Chemical Communications front cover! A huge thanks to Karl Harrison for making it possible! McDonald Lab @ The Crick Morgan Jones

Great to meet karl hoffmann this week at the University of Aberystwyth. Looking forward to work ahead!

We are very proud of Jess Reynolds for winning the prize for the best talk (& title of European Champion!) at the EFMC YMCS meeting. She won the best talk at the RSC BMCS meeting last year to go forward to the Champions League in Basel! SBM CDT Oxford Chemistry

Our pre-print on the development of ligands for a bromodomain-containing protein from Schistosoma mansoni is now available ChemRxiv. We have identified ligands for both bromodomains from SmBRD3, and used a structure-based approach to optimize them. chemrxiv.org/engage/chemrxi…

Hot off the press! Check out our ‘mutate and conjugate’ paper in ACS Publications Bio & Med Chem Content 🔥 Here we demonstrate that combining site-directed mutagenesis and reactive fragments can be used to rapidly identify selective covalent probes for target validation studies.

(1/8) Please to present our work on functional group tolerant C-C bond forming hydrogen borrowing enolate alkylation reactions with Smith Group Donohoe Group Oxford Chemistry SBM CDT: bit.ly/46QXWRh

In ChemRxiv we (in collaboration with Smith Group) show that hydrogen borrowing can be a remarkably mild and functional group tolerant process: bit.ly/46QXWRh Well done Elliot Bailey, Oxford Chemistry, SBM CDT

Here's a bit more detail on this paper. When discussing our work on NI-Pano (sciencedirect.com/science/articl…) we were often asked how we knew where the prodrug was being released. So we designed a new prodrug incorporating the fluoroethyl epitope of the antibody-based...

Our paper on inhibitors of the Schistosoma mansoni bromodomain SmBRD3(2) is online in J Med Chem (ACS Publications Bio & Med Chem Content). Congrats to Matthias Schiedel, Darius McArdle, Gilda Padalino, Anthony K. N. Chan and the other authors. Great (ongoing) collaboration with karl hoffmann pubs.acs.org/doi/10.1021/ac…

Delighted to share our paper targeting a bromodomain of S. mansoni! Thanks to everyone involved. I look forward to seeing future work from the Conway and Hoffmann group collaboration!

Very exciting to see Klemensas Šimelis’ #phdresearch on targeting TET #enzymes using #cyclicpeptide inhibitors in #Bioorganic & #MedicinalChemistry! A great collaboration with the Suga group & Schofield Group. Read Klem's paper online: sciencedirect.com/science/articl… #chemicalbiology

Very pleased to share that my PhD work from University of Oxford/SynBio CDT with Stuart Conway is now live on BioRxiv - we designed pairs of orthogonal IMiD analogues and ZF degrons for use in target validation & beyond. biorxiv.org/content/10.110…

Our work investigating the functional group tolerance of the hydrogen borrowing enolate alkylation method now out in full form! Smith Group Donohoe Group Oxford Chemistry SBM CDT nature.com/articles/s4146…

Check out this amazing work spearheaded by our very own Elliot Bailey! Congratulations to Elliot for making great strides in hydrogen borrowing Oxford Chemistry nature.com/articles/s4146…