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I’m beyond excited to share work from my PhD, co-led with Alicia Braxton, out today in Nature! We used CODA to map the anatomic and genomic properties of pancreatic cancer precursors. Led by the amazing Laura DeLong Wood and Denis Wirtz ! nature.com/articles/s4158…

Patients with immunodeficiency are often undiagnosed or experience marked delay in detection. #AI to the rescue. science.org/doi/10.1126/sc… Science Translational Medicine Manish Butte UCLA

The 2024 Convergence Symposium & Poster Session is approaching! Learn more, register, and submit your poster abstracts here: convergence.jh.edu/convergence-sy…

The 2024 Convergence Institute Symposium & Poster Session is tomorrow! Visit our website to learn more #ConvergenceSymposium2024 convergence.jh.edu/convergence-sy…

Preclinical #OpenAccess study in JCI insight by Won Jin Ho @FertigLab Dr. Elizabeth Jaffee et al Johns Hopkins Kimmel Cancer Center Phosphodiesterase-5 inhibition collaborates with vaccine-based immunotherapy to reprogram myeloid cells in #PancreaticCancer insight.jci.org/articles/view/…

I am happy to share our recently published paper on Cell Systems. In this study, we developed an integrated experimental and computational approach to profile PanINs and examine the surrounding microenvironment. sciencedirect.com/science/articl…

A semi-supervised imaging, spatial transcriptomics, and single-cell workflow uncovers transitions of PanIN progression and the surrounding microenvironment. Luciane T Kagohara 🇧🇷🧬👩🏻‍🔬👩🏻‍💻 @FertigLab cell.com/cell-systems/a…

🎉 🎉 Excited to share our latest research, now in Nature Cancer IrAEs can be associated with significant morbidity or mortality - our study suggests that targeting IL-17A CD4+ T cells could help manage these side effects better, and paves the way for 🎯 treatment approaches

New preprint from Luciane T Kagohara 🇧🇷🧬👩🏻‍🔬👩🏻‍💻 @FertigLab Dr. Elizabeth Jaffee Won Jin Ho Ashley Kiemen Ashi_W & colleagues Johns Hopkins Kimmel Cancer Center Convergence Institute Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in #PancreaticCancer immunotherapy

And Anirban Maitra was again faster to post! On an amazing teamwork led by Dimitri Sidiropoulos, we were able to profile PDAC tertiary lymphoid structures induced by immunotherapies. A quick thread below.

finally out in full form - i'm excited to share our work showing the utility of adding a PDE-5 inhibitor onto vaccine (msln-listeria) to reprogram the myeloid cells in PDAC - led by the amazing Nicole Gross carter zhang, also jacob mitchell @FertigLab insight.jci.org/articles/view/…

incredible work led by Dimitri Sidiropoulos to peruse through the TLS forming in PDAC - a great show of making the most of multiple state-of-the-art tools to synthesize our understanding

Science is cool 😎 Our recent article in Nature Cancer has been selected for the journal cover! 🎉 It is an honor to see our research featured in such a prestigious journal, pushing forward the boundaries of immunotherapy. Special thanks to Phil and F. Sella Akoya Biosciences 🙏🏻

BC^3 is BACK! Join us for our opening keynote on Wed, October 16th at 11 AM EST. Dr. Joe Craft is sure to give an excellent lecture. #freeseminars #Bcells #TLS Daniel Hollern

Really enjoyed leveraging latest workflow tricks. The ability to batch 30+ samples per run by live-cell barcoding for CyTOF enhanced the rigor of the analysis + Soren Charmsaz and Nicole Gross employed CytoNorm (Sofie Van Gassen) to further normalize the data across batches.

1/8 Excited to share our latest study in Nature Immunology led by @DanielShuMD on TLS in #HCC patients treated w/ neoadj ICB: ⏩ TLS linked to improved outcomes ⏩ Novel "involuted" TLS found in tumor regression zones 🔗 nature.com/articles/s4159…

What an eventful week in Houston filled with impactful science & great people! Super grateful to receive a Society for Immunotherapy of Cancer young investigator award to present our work on TLS in neoadj. treated PDAC. Also huge thanks to Break Through Cancer & MDA for a productive and inspiring Summit!

We’re so excited to present LISH-LnR, a powerful spatial transcriptomic platform spawned in my lab at Johns Hopkins and then spun into a startup company called Portal Bioscience. biorxiv.org/content/10.110…

The first manuscript from my fellowship research investigating apCAF biology in mouse PDAC tumors is now on bioRxiv!

PIVOT is a very useful open source tool from Ashley Kiemen André Forjaz Denis Wirtz and colleagues at Johns Hopkins Kimmel Cancer Center that allows for co-registration and integration of multi-omic spatial data (eg, Visium, cyclicIF, imaging mass cytometry). Preprint: biorxiv.org/content/10.110…