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Context is everything! Helpful framing for patient care when talking about CHIP. Inspiring work as usual from Mrinal Patnaik

pubmed.ncbi.nlm.nih.gov/37522274/ #hemepath #Pathtwitter #PathX Kamran Mirza MD PhD - کامران مرزا Cullen Lilley, MD, MS, MA, MB(ASCP)

A great population-level look into risks of AML and MDS in DDX41 germline and somatic variants. Low rates of CH in germline but an elevated MCV may portend evolution! ashpublications.org/blood/article/…

New research: Cigarette smoke stimulates clonal expansion of Jak2V617F and Tet2-/- cells: Introduction Somatic mutations in myeloid growth factor pathway genes, such as JAK2, and genes involved in epigenetic regulation, such as TET2, in… #oncology frontiersin.org/articles/10.33…

Another excellent MPN-AP/BP review (by @arampotas @donalmclor et al) - much needs to be done for our patients with with disease! #mpnsm #leusm onlinelibrary.wiley.com/doi/10.1111/bj…

Excited to share our commentary on novel work by Ramanathan and colleagues demonstrating how cigarette smoke can affect clonal dynamics frontiersin.org/journals/oncol…

Happy to share our work identifying common pathways promoting heightened innate immune cell activation with loss of either Dnmt3a or Tet2, the two most commonly mutated genes in CHIP, in the context of atherosclerosis. nature.com/articles/s4416…

Current studies examining putative risk factors of CHIP are cross-sectional. Led by M Mesbah Uddin Mohammad Saadatagah &w Christie Ballantyne, we use longitudinal exome seq of 4,187 over 21y to better prioritize clinical & genetic risk factors for incident CHIP. medrxiv.org/content/10.110…

Enrichment of TET2 clonal hematopoiesis among individuals w HFpEF v controls & adverse prognosis among those w TET2 CH + HFpEF. Murine model recapitulates HFpEF exacerbation in Tet2-deficient v WT bone marrow ahajournals.org/doi/abs/10.116… Circulation [1/2]

Our report on CHIP and infection risk in the UK Biobank is out now Leukemia Journal. nature.com/articles/s4137… We illustrate the importance of accounting for incident myeloid cancer development in observational studies of CHIP, particularly when the observation period is very long.

Germline DDX41 mutant predisposition syndromes: Slow driver states to hematological malignancies. pubmed.ncbi.nlm.nih.gov/37705260/ Unanswered questions and future directions Tim Chlon #DDX41 #Myeloid #Germlinepredisposition AmericanJournalofHematology Mayo Clinic Comprehensive Cancer Center Mayo Clinic Center for Individualized Medicine

Excited to share our review of CH and inflammation covering clinical applications, pre-clinical mechanisms, and next steps in the field. Thanks to co-authors at Mount Sinai Hematology/Oncology Fellowship and The Tisch Cancer Institute. Online now Critical Reviews in Oncology Hematology (CROH). sciencedirect.com/science/articl…

Congratulations Jon Anker, MD, PhD! So proud of our amazing fellows Mount Sinai Hematology/Oncology Fellowship

Conceptually flawed paper from deCODE on #CH in Nature Genetics today TLDR: Different clones have distinct disease profiles so lumping distinct forms of CH together is uninformative. #CHIP is associated with CVD in both smokers and non-smokers in full UKB 🧵nature.com/articles/s4158…

Such an important reference for those doing #CHIP research from a true leader in the field Kelly Bolton MD PhD Thanks for sharing your knowledge. 💡 How low can you go?: Methodologic considerations in clonal hematopoies... sciencedirect.com/science/articl…

Our proteomics analysis of the large CANTOS CV trial is now online Blood Advances led by Janghee Woo (now Winship Cancer Institute of Emory University). Clonal hematopoiesis was associated with incident anemia & markers of inflammation which were attenuated by IL-1b inhibitor therapy. ashpublications.org/bloodadvances/…

Thrilled that our commentary on National Comprehensive Cancer Network (NCCN) guidelines for interpreting TP53 variants in the context of CHIP versus mosaic LFS is finally out! Many thanks to our wonderful collaborators and reviewers The Tisch Cancer Institute JCO Precision Oncology ascopubs.org/doi/10.1200/PO…

In a cross-sectional study, investigators describe distinct patterns of myeloid and lymphoid clonal hematopoiesis by inflammatory bowel disease type, age, and treatment vs controls medrxiv.org/content/10.110… medRxiv

We just published ! Clonal hematopoiesis of indeterminate potential in Crohn's Disease and Ulcerative Colitis. Great work by first authors Myvizhi Esai Selvan and Daniel Nathan from Mount Sinai Genetics The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai IBD Mount Sinai academic.oup.com/ibdjournal/adv…

Should we be screening IBD patients for CHIP? Proud of this multi-disciplinary collaboration describing the risk for CHIP in IBD. Thanks to Dr. Zeynep Hülya Gümüş 🕊️ Myvizhi Esai Selvan Bridget Marcellino and many others The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai IBD Mount Sinai doi.org/10.1093/ibd/iz…