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New tube holders in the lab👇👇🏽👇🏿

📣Thrilled to announce that our latest paper entitled "Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement" is now published in Advanced Science!🎉 #confinement #mechanobiology Find the paper here: onlinelibrary.wiley.com/doi/10.1002/ad…

🚨 NEW WORK OUT 🚨 Led by Hawley Pruitt and with Ashi_W Tamara Lotan, MD and the Eisinger lab at UPenn - we find that CD4+ T cell motility is inhibited in a collagen VI-rich matrix, seen in prostate tumors. Check it out! 👇authors.elsevier.com/a/1hIiA,LVEyDF… Extracellular Matrix News

Check out our latest review by Jiyeon Song in ATVB: An AHA Journal about hydrogels to mimic the ECM to modulate vascularization!

So happy to have our work out in nature! An amazing collaborative effort across the Garry P. Nolan Michael Snyder, PhD William J. Greenleaf labs. Article: nature.com/articles/s4158… Small subset of what we did/found below (1/8):

Tour de force review by Dafu Wang and Travis Brady with SanthanamLab@JHUSOM on how the ECM mechanics regulate vascular homeostasis and dysfunction, just coming out in Nature Cardiovascular Research! nature.com/articles/s4416…

Our latest Perspective by Sharon Gerecht & colleagues discusses how microenvironmental cues from the extracellular matrix guide macrophage-endothelium interactions, and how biomaterials can be used to replicate these interactions: nature.com/articles/s4157… Ya Guan @Gerechtlab

Please consider donating! gogetfunding.com/chem-e-car-tea…

The Gerecht Lab is currently hiring! We’re looking for a postdoc with expertise in stem cell biology and the use of microfluidic platforms for cellular studies. Check out the job posting here! 👇 academicjobsonline.org/ajo/jobs/26668

🎉 Exciting news! Our paper on breast cancer mechanobiology is published in Cancer and Metastasis Reviews @springerNature! Special thanks to my student Ayuba, our collaborators Robert Arnold, Ph.D. “Rusty” L. Adriana Avila and funding sources Breast Cancer Research Foundation of Alabama NIH. Check it out: link.springer.com/article/10.100…

ΕΙΜΑΣΤΕ ΣΤΟΝ ΤΕΛΙΚΟ!!! / WE ARE THROUGH TO THE #UECLfinal !!! 🔴⚪🇬🇷 #Olympiacos #WeKeepOnDreaming #UECL

We're honored to be featured as the NAVBO lab of the month for May!! navbo.org/members-labs/

Some photos from Dr. YingYu Lin's (YingYu Lin) hooding ceremony yesterday!!! Could not be more proud of her and all her accomplishments leading up to this milestone 🎓🎓🎓🎓 Johns Hopkins ChemBE Johns Hopkins Engineering

WE ARE THE @europacnfleague WINNERS! WE ARE THE CHAMPIONS! 🔴⚪🏆🇬🇷 #Olympiacos #UECL #Champion #Winners #Europe #Greece #WeKeepOnDreaming

Oncogene-->ECM composition-->ECM organization -->T cell fate! With Eisinger Lab leading, we show that YAP1 promotes collagen VI deposition in sarcoma, leading to the remodeling of fibrillar collagen, which in turn causes CD8+ T cell dysfunction. jci.org/articles/view/…

Excited to share our new study in Cell Reports! 📜Fluid forces cause cells in tight, but not moderate, confinement to move upstream. Key players: Lamin A/C, actomyosin, calcium, and NHE1. Read more: cell.com/cell-reports/f… @NIGMS Breast Cancer Research Foundation of Alabama Auburn University Ginn College of Engineering #confinement

First full day of sessions at BMES 2024 has gotten off to a great start with Dimitris Ntekoumes presenting work on our on-demand hypoxic hydrogels! Looking forward to the rest of our time here in Baltimore!

Introducing Dr. Ntekoumes! So proud of all you've accomplished and congratulations on an amazing defense! Dimitris Ntekoumes

🚨Check out our latest work! Led by Ya Guan, we use an engineered matrix to show that stiffening induces M2 macrophage polarization in 3D, mediated by CaMKK2, with implications for tumor development and wound healing. #biomaterials #macrophage advanced.onlinelibrary.wiley.com/doi/full/10.10…

We dared. We dreamt. WE DID IT!!! 🏆