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I'm excited to share our preprint on the molecular properties of transcription factor protein isoforms: biorxiv.org/content/10.110…

New paper in Nucleic Acids Research. We use in vivo barcoding to reduce the cost and hands-on time of library prep for Oxford Nanopore plasmid sequencing. academic.oup.com/nar/advance-ar…

Excited to finally see our paper on the yeast pan-transcriptome in Nature Genetics. Insight from 1,032 yeast transcriptomes emphasizes the essential contribution of accessory genes to transcriptional patterns at a species level. European Research Council (ERC) Institut universitaire de France (IUF) nature.com/articles/s4158…

Yachie lab 2024

Our latest work on developing a potent and specific tool for activating or repressing endogenous splicing events is out! authors.elsevier.com/c/1jJci3vVUPRm…

Pleased to to share the final version of our paper identifying novel cancer driver genes in pancreatic cancer out now in Nature Communications. Thank you so much for this great team work led by Sebastien Martinez et al. at LTRI @sinaihealth. sinaihealth.ca/news/sinai-hea…

My Sensei is famous:)

Bu zamana kadar yaptığımız en iyi bilimsel çalışma ☺️

The genetic architecture of protein stability by Andre Faure @ajfaure.bsky.social Aina Martí cristina hidalgo-carcedo @ToniBeltran13 Joern Schmiedel nature.com/articles/s4158… Centre for Genomic Regulation (CRG) Wellcome Sanger Institute ALLOX

Another beautiful systematic screen as usual! Congratulations everyone involved!!

Please circulate and come! Hirohide Saito/齊藤博英 and I will co-organize a symposium "Genetic Gimmicks" at MBSJ2024 第47回日本分子生物学会年会. Day 3 in Room 1. We got speakers who love delving into biology and biological tools. Hideaki E. Kato ただの院生 Ryosuke Kojima Sherry Shiying Aw

Spatial proteomics is crowned Method of the Year! 🎉 Explore our groundbreaking work on bringing proteomics into 3D (yes, spatial! 😉): cell.com/cell/pdf/S0092…. And don’t miss my latest review on 3D spatial omics using tissue-clearing and AI: nature.com/articles/s4159…. 🚀

We are proud to present "ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma" led by Charlie Barker Sumana Sharma in collaboration with EPIC-XS Utrecht, Protavio Ltd Wellcome Sanger Institute and UofAthens biorxiv.org/content/10.110…

Please circulate! Chan Zuckerberg Initiative and STELLAR SCIENCE FOUNDATION (SS-F) have started the Global Science Scholars program to exchange postdocs between the US and Japan. yachielab in Osaka University is one of the host labs in Japan side. czbiohub.org/program-ssfcz-…

We UBC School of Biomedical Engineering are moving to this newly constructed building before the holidays…! Feeling we can grow crazily from here.

Thank you again NRC Canada, UBC School of Biomedical Engineering, yachielab, and many others for this incredible opportunity!

New (and hotly anticipated - at least by me) preprint from my group describing a better way to partition training data for genomic-trained models to solve the long-neglected problem of homology-based data leakage. Thread from first author Abdul Muntakim Rafi 👇

CloneSelect published in Nature Biotechnology. Please check out this GIFtorial. This retrospective clone isolation method using CRISPR base editors is a powerful tool in broad biology. A history of Soh Ishiguro in yachielab. nature.com/articles/s4158… UBC School of Biomedical Engineering 東京大学先端科学技術研究センター 大阪大学PRIMe