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📢 Historic day for Portugal and phage therapy! 🇵🇹 A framework was approved, allowing magistral preparation of personalized phage products. 🙌 Grateful to Jean-Paul Pirnay, my group Azeredo Lab Portuguese patients, and doctors who signed a petition inspired by the Belgium model.

Exciting times! Our latest preprint is now live 🤩! I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n biorxiv.org/content/10.110…

Very happy our paper on Zorya anti-phage defense system is now published in nature! 🥳 Big congrats to first authors haidai HU and Philipp Popp and all other authors! Wonderful collab with Marc Erhardt and SimonJackson #cryoEM CPRatUCPH Københavns Uni nature.com/articles/s4158…

Excited to share our latest collab with Wenyuan Han's Lab! 🚨 Bacteria use dITP as an immune signal to activate NAD+-depleting effectors. Phages counter immunity by destroying dAMP (dITP precursor)! 💥🧬 Preprint 🔗: biorxiv.org/content/10.110…

🔥New paper! 🔥 Distribution of bacterial DNA repair proteins and their co-occurrence with immune systems (cell.com/cell-reports/f…) It started with a simple question: Are certain prokaryotic immune systems always (or never) encoded with specific DNA repair proteins?...

New year, still a postdoc

🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵

Claire's paper now entitled "Multi-interface licensing of protein import into a phage nucleus" is now published here: nature.com/articles/s4158… Claire Kokontis used classic genetics to figure out how proteins are selected for import into a "phage nucleus" Some notable additions:

After many years in the making, this story is finally published! In the updated manuscript on BREX DNA recognition, we reveal that modifying the system's specificity can surprisingly enhance anti-phage defense. nature.com/articles/s4146…

Pleased to share that my main Sir Henry Wellcome Fellowship project is now published! This study provides mechanistic insights into Zorya II function. Grateful to all who contributed! Read it here:tinyurl.com/ZoryaII

Absolutely honored to receive this year’s MarBiNa Prize! Huge thanks to the IBiNa committee, my incredible PhD mentor kathaRiNA Höfer , and the entire Höfer team. Big thanks to New Concepts in Prokaryotic Virus-Host Interaction & IMPRS-μLife, of which I was a part. Grateful to everyone who shared this special moment with me!

And here it is, the completed BASEL collection finally published as early access in PLOS Biology - see the thread for more details. 🤗🧬🎣

Traveling home from the absolutely exciting bacterial immunity meeting in Paris 🧬☀️🚅. Many thanks to the organizers and especially local host Aude Bernheim Aude Bernheim + team MDMLab for setting this up!

And it is out in npj Antimicrobials and Resistance ! nature.com/articles/s4425…

White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the Didier Mazel lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones. science.org/doi/10.1126/sc…

Out now in Molecular Cell: Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA cell.com/molecular-cell… Most long-A pAgos interfere with invading DNA solo. Why then are cyanobacterial pAgos co-encoded with a Cas4-like protein? A 🧵

🎙 New Episode Out! In this episode, we had the pleasure of talking with Alexander Harms researcher and professor at ETH Zürich, about a well-known resource in phage biology: the Basel Phage Collection. Listen here: open.spotify.com/episode/3ndSV6…

Excited to see our work published in Science Advances! We present RBPseg, a method for structural prediction of #phage receptor-binding proteins. We applied it to diverse tail fibers and validated the predicted structures using #cryoEM. Read here: science.org/doi/10.1126/sc…

Our review on the versatile roles of phage-encoded tRNAs is out. Great work Daan F van den Berg authors.elsevier.com/a/1lHYB,L%7EyC…

Phage DNA modifications evade defense: Phage DNA modification adds arabinose to cytosines via hydroxy linkage(5ara-hC) w/potential double & triple arabinosylation. Arabinosylated phages are protected from DNA-targeting CRISPR-Cas & restriction modification cell.com/cell-host-micr…