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Tweetorial about Stephan Daetwyler and my attempt to forecast the future of light-sheet scopes. Happy to pass our orbuculum along, if someone wants it.

Some fishy imaging from Stephan Daetwyler and me for #FluorescenceFriday .

How do you image the large and the small at the same time? We developed new 🔬 technology to image centimeter-scale specimens - including whole mouse brains 🧠 - with diffraction-limited resolution and without sectioning. #mesoscale #imaging biorxiv.org/content/10.110… 🧵 (1/n)

Blood flow in a Zebrafish embryo, imaged at 10Hz. Imaged with Stephan Daetwyler on the meso OPM. Downsampled as a courtesy of twitter (original video is 3200x700 pixels and 100 frames long).

We present a meso Oblique plane microscope. A microprism below the sample tilts the sheet, improving resolution and sectioning with a low magnification objectives. We analyzed blood flow in zebrafish embryos at 12Hz. biorxiv.org/content/10.110…

I am very excited to share my postdoc work “Morphodynamics of human early brain organoid development”,  where we take a multiscale morphodynamic view of human brain organoid development. In collaboration with Gilles Gut  Gray Camp Treutlein lab biorxiv.org/content/10.110…🧵(1/9)

Our mesoscopic oblique plane microscope is online: opg.optica.org/optica/fulltex… It enables rapid volumetric imaging of a whole zebrafish embryo with ~2.3 micron lateral resolution. This is enabled by merging a couple of optical innovations and tricks. 1/N

Thrilled to present one of my works in the Prinz lab as preprint! We find BLTP2 controls phospholipid composition and fluidity of the Plasma Membrane (PM), and tumorigenic features of cancer cells, putatively by transporting PE lipid from the ER to PM. biorxiv.org/content/10.110…

We present oblique plane microscopy with adaptive optics (AO): biorxiv.org/content/10.110… One deformable mirror corrects both the light-sheet and the fluorescence detection. Movie shows cancer cells in a zebrafish xenograft model, before and after application of AO.

We present projection imaging with parameter selection (PROPS) for light-sheet microscopy. rdcu.be/dCVmA With PROPS, we can control the depth and location of a projection, and optically unwrap a curved surface, here of a drosophila embryo. Invention by Bingying Chen !

A projective light-sheet microscopy approach for functional imaging in whole animals Bingying Chen Bo-Jui Chang Stephan Daetwyler Reto Fiolka Lyda Hill Department of Bioinformatics #BiotechNatureComms nature.com/articles/s4146…

We had the honor of hosting the Foreign Affairs Committee of the Swiss Parliament. Our Chair Gaudenz Danuser & postdoc Stephan Daetwyler presented their science & experiences as Swiss expat researchers (both trained at ETH Zurich). #EngagedCommittee #ImpactfulQA

We have integrated adaptive optics in an oblique plane microscope, where one deformable mirror corrects both the light-sheet and the fluorescence detection. opg.optica.org/boe/fulltext.c… Figure: cancer cells in a zebrafish xenograft model, before and after application of AO. 1/4

It wouldn’t be a fish meeting without a Twitter/X photo-op! #RockOn #ZDM17 ZDMSociety