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Structure of the human SAGA coactivator complex is out today at NatureStructMolBiol! - we determined the architecture and structure of hSAGA and comp. non-conserved features with ySAGA revealing dramatic rearrangements and insights on the splicing mod and disease nature.com/articles/s4159…

Introducing PAPA (proximity-assisted photoactivation), a new approach to detect molecular interactions in live-cell single-molecule imaging. Thomas Graham Xavier Darzacq biorxiv.org/content/10.110…

We’re hiring for a Tissue Culture Specialist! Please RT and see job ad below

It's our labs 1st birthday! It's been a ton of fun getting things going & assembling a team of great colleagues (Apratim (Appy) @alanboka1 kaeli mathias and more not on twitter). As a treat, here is a video of our MOSAIC microscope build. Lots of beautiful imaging ahead!

What if enhancers worked w/o contacting promoters? What if functional PTMs were on diffusible proteins, not histones? And what if diffusion, not looping, bridged CREs to their targets? We think it's possible. Check out our new perspective to see how: genesdev.cshlp.org/content/early/…

Our paper was just accepted at Cell Systems 🥳 Human acidic transcriptional activation domains require both acidic and hydrophobic residues. 8 residues is enough to accurately predict human activation domains. Preprint: biorxiv.org/content/10.110…

It's time for #ScientistoftheWeek! This week we will be taking a look into the #life of Dr. Robert Tjian, Professor of #Biochemistry & #MolecularBiology at UC Berkeley and an Investigator of HHMI. His work on eukaryotic #transcription has us #excited to learn more! #SciComm

Interested in doing Single-Particle Tracking (SPT) experiments and analysis? Check out our new protocol paper by Asmita Jha (she/her) that goes through how to carry out SPT step-by-step with a focus on transcription factor tracking in mammalian cells: link.springer.com/protocol/10.10…

Our new paper came out today! Open Access at Cell Systems sciencedirect.com/science/articl… 1) Human acidic activation domains must balance acidic residues with aromatic and leucine residues. 2) This balance accurately predicts new acidic activation domains.

I am thrilled to be organizing the Women in Imaging + Industry Applications bootcamp August 3-11! Geared to incoming grad students, we will cover basic optics, hands-on demos, nano-rotations, and company tours + build community among women microscopists in the Bay! 👩🏾‍🔬👩🏻‍🔬👩🏼‍🔬🔬🧫

We have 9 spots left, so please sign up before Monday! We are open to all Berkeley grad students, but particularly encourage incoming first years to sign up for this FREE bootcamp. #WomenInSTEM #Microscopy #AcademicTwitter

My review went live today. I argue that transcription factors find their binding sites using both protein-protein interactions and DNA binding interactions. It's halfway between a review and a perspective. academic.oup.com/genetics/advan…

Proximity-assisted photoactivation (PAPA) is a new way to detect protein-protein interactions in live-cell imaging, which uses excitation of a “sender” dye like JF549 to reactivate a “receiver” dye like JFX650 from a dark state. elifesciences.org/articles/76870 (1/7)

Our new review on single molecule tracking and it’s applications to transcription is out now! Liza Dahal Nike Walther Thomas Graham Xavier Darzacq Biochemical Society #BiochemSocTrans portlandpress.com/biochemsoctran…

I am super proud of this piece authored by lena vantablackmon 🦠🔬💻 (depreciated) and I - we synthesized stats on #gender #diversity in the #imaging and #optics field and how academic + career bootcamps like ours at Cal can increase #belonging for women in optics. 🔬👩🏾‍🔬👩🏻‍🔬 onlinelibrary.wiley.com/doi/10.1111/jm…

How is chromatin binding of the Type 2 nuclear receptor (T2NR) network regulated? New work out now on bioRxiv led by Liza Dahal w/ Thomas Graham Gina Dailey Alec Heckert Xavier Darzacq biorxiv.org/content/10.110…

A major limitation for #genetherapy is delivering large cargo with #AAV. We know that AAV vector DNA concatenates into large episomes in the nucleus, but how does this happen? Led by Anna Maurer we built a system to watch AAV vector genomes in live cells 1/ 🧵

Come and join us! We are looking to recruit a Research Assistant/Technical Associate I to join our team Summer 2024. This could be an ideal position for someone looking for 2 years of research experience before starting graduate school. Apply: careers.peopleclick.com/careerscp/clie…

New study on #transcription regulation in human #placenta development - we find that the transcription factor #TFEB is required for the differentiation of a fusing cell type in the placenta (syncytiotrophoblasts) by controlling cell-cell fusion! biorxiv.org/content/10.110… 🧵