🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

A surprising link between lysosomal degradation of mitochondrial DNA mediated by PLD3, STING, and endo-/lysosomal APP degradation from (twitterless) Wim Annaert & Zoe van Acker: rdcu.be/dc8jJ

Why is age the main risk for Alzheimer’s disease? Mouse models reveal that the loss of myelin integrity is causally linked to enhanced plaque deposition. Great work by ⁦Dr. Constanze Depp⁩, ⁦@TingSun_MPINAT⁩ et al. in Nature nature.com/articles/s4158…

PLD3 degrades mitochondrial DNA to keep nucleotide signaling and APP metabolism in check VIB-KU Leuven Center for Brain & Disease Research Leuven Brain Institute KU Leuven Research nature.com/articles/s4146…

And that wraps up a great #NCL2023 in Hamburg. Australia and #NCL2025 Steph Hughes here we come. The #battendisease bell 🔔 is passed on.

Don't miss our paper on #microglia #biomarkers in Molecular Neurodegeneration 🧠 We used a translational approach to study the #proteome and #secretome of microglia 🐀🧫👥️ Check out the paper for our six selected biomarker candidates! #FTD #Alzheimers #iPSC x.com/MolNeuro/statu…

Out now! A wonderful collaboration with @Carmine21678 to highlight all the ordinary and extraordinary roles of the lysosome! Thanks Nature Reviews Molecular Cell Biology

White is not a marker of microtubules but when this protein is transfected in COS7 looks like this. What protein is it ? and why looks like this? Cyan=Lysossome Yellow=mitochondria #FluorescenceFriday challenge.

Don't miss this meeting... great speakers covering Lysosomes & Autophagosomes content! June 6 – 7, 2024 in Berlin, Germany. lysosomes2024.de

Having a great time at our FOR2625 symposium in Berlin with great science of our FOR2625 members and amazing external speakers from around the world 👌😀

More than happy to finally see our paper out in Nature Cell Biology! We de-orphanized MFSD1 as a lysosomal dipeptide uniporter. Fantastic work of @Kathaschnatta, Océane Guelle, Loew Group and Bruno Gasnier: nature.com/articles/s4155… so nice to see the structure of MFSD1&GLMP!

💫NEW: Markus Damme, Loew Group, Gasnier & co show in an Open Access study that MFSD1 is a #lysosomal dipeptide uniporter providing an additional route to recycle lysosomal #proteolysis products to lysosomal amino acid exporters. nature.com/articles/s4155…

I'm hiring! Interested in lysosomal biology and/or lysosomes and neurodegeneration? The Damme lab is recruiting PhD students and PostDocs! DM or tinyurl.com/yrv4bh22 Get in touch with me! Repost & spread the word!

Cells sense high lysosomal membrane tension - as can happen in some lysosomal storage disorders - and activate transcriptional programs to help tissues deal with this stress. Huge congratulations to Ruiqi Cai Spencer Freeman and others! rdcu.be/dNyYD

Plekhg5 controls the unconventional secretion of Sod1 by presynaptic secretory autophagy nature.com/articles/s4146…

Don't miss the 2025 Gordon Conference on "Lysosomal Diseases" in California (March 2 - 7, 2025)! grc.org/lysosomal-dise…

Our new paper on the proteolytic processing of TMEM106B is out in Cell Reports ! TMEM106B undergoes physiological shedding and additional C-terminal trimming. The new luminal-domain antibody is commercially available! sciencedirect.com/science/articl…

🚨New job post alert 🚨 We are looking to recruit a talented in vivo scientist to support our growing Parkinson's disease portfolio. Please reach out if you are interested in learning more! denalitherapeutics.com/job?id=0844a51…

Our next ESGLD webinar is scheduled! Very happy to announce that Dimitri Krainc will tell us something about his exciting story how the Commander Complex affects #lysosomal function. For those of you which are not ESGLD members yet, please register with our secretary...