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88 y.o. M, bladder TURBT specimen. What is the diagnosis? #GUPath Mass General Brigham Pathology

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1/2 Kindly share your thoughts: Subtotal hysterectomy 50 year old woman with 3 years history of abnormal uterine bleeding. Mitoses ~4-6/10HPF, No necrosis. Preliminary thoughts-IMT, STUMP #Gynpath #PathTwitter #BSTPath #pathology

Olaleke Folaranmi Trupti Mandalia Kyle Devins, MD Katja Gwin M.D. Rana Saleh, MD Amany Hassan Esther Adler, MD Anne Mills Dan Graham syed t. hoda Greg Charville To me, it looks more smooth muscle than IMT, but have you tried ALK IHC? Also, for STUMP versus LMS, this algorithm might be helpful. I’ve cited the paper here for your reference. It was also discussed at USCAP 2025 a couple of times and we sometimes use it at our institution,

Feeling old. Can someone please explain to me what “new age drinks” are?

20s M postauricular polypoid mass. Dx? #dermpath #PathTwitter #pathX

Dan Graham Tristan Rutland MBBS FRCPA IFCAP Dan, I had the same thought. The paper below (PMID: 24441657) mentioned that papillary cystadenomas of the epididymis and broad ligament have identical morphology and IHC staining with clear cell papillary renal cell tumor. The diagnosis of papillary cystadenoma can be

39 y.o. M, partial nephrectomy. What is your diagnosis? Mass General Brigham Pathology MGH Pathology

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GROSSnosis & Annotations | 👇 ◆Site: 🦵Knee joint | 16x12cm ◆Diagnosis:🔬Tenosynovial giant cell tumor, diffuse type Ace My Path #pathoutpic #pathx #BSTpath PathologyOutlines.com #pathresidents #gross

Thanks for all of your great thoughts. EMA, desmin, Beta-catenin/LEF1, STAT6 negative. Pending Rb, MDM2, claudin1, GLUT1, MUC4 IHC, then, depending, +/- PHF1 FISH. Any other ideas?

A comprehensive review of literature on SS18::POU5F1-fused sarcomas accompanies the case report, discussing differential diagnoses and possible histogenesis. This contributes to understanding this uncommon tumor type and its clinical implications. bit.ly/4jhPoIF

50s F 17cm abdominal mass. Beta-catenin: Favor -, but some equivocal nuclei LEF1: Dead - SMA: Focal weak + Desmin: Focal dendritic type staining S100, STAT6, CK, ER, calret, inhib, CD117, DOG1 - Dx/further w/u? #PathTwitter #PathX #BSTpath

retroperitoneal mass core biopsy from a middle-aged M thoughts?

Melanoma can occur in Mucosal Sites like Rectum, Sinonasal, Vaginal Wall I always found this interesting because we usually associate it 🦀 with skin ☀️ Melanocytes are Neural Crest Derived 👶 and they migrate to the mucosa (as well as skin). #pathx #embryology #peds

80s M iliac sclerotic & lytic lesion w/ soft tissue extension w/ calcifications. Also w/ multiple thigh soft tissue masses, bx from one of them. Dx/workup? #BSTpath #PathTwitter #PathX

60s M 20cm thigh mass. S100=very few scattered cells; SOX10= scattered cytoplasmic staining; PRAME=80% of cells +; CK, desmin, SMA, h-caldesmon, CD45/43, ALK, MYOD1, CD34 etc negative. Dx/workup? #BSTpath #PathTwitter #PathX

16 y.o. M, orchiectomy. What is your diagnosis? The gross photo is in the chat. #PathTwitter Mass General Brigham Pathology MGH Pathology