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Check out our new paper that brings us another step closer to understanding how the amazing IL-17A–secreting γδ T cells develop. A big thanks to Stefania Martin and Daniel J Pennington for their help and support, always. stke.sciencemag.org/content/14/692…

As summarized yesterday, Omicron 80% less likely to cause hospitalizations for COVID-19. Problem with a highly transmissible variant if you swab everyone's noses in hospital (which we do) is need to distinguish between being there WITH vs FOR COVID bloomberg.com/news/articles/…

Real-world data on Omicron from UK similar to data from S. Africa on Omicron being 60% less likely to result in hospitalizations than Delta (in S. Africa, 70% less likely compared to delta; 80% lower risk of hospitalization than previous COVID waves) washingtonpost.com/world/europe/o…

Why so excited Paxlovid/molnupiravir? Updated data from CDC today shows rate of hospitalization among unvax'd 67.8/100K & rate among vax'd 3.9/100K (typical flu hospitalization rate 20-40/100K). We now have way to prevent hosp in unvax'd covid.cdc.gov/covid-data-tra…

I’ve seen a lot of Covid in the ER recently. With so many people getting infected recently, some folks may wonder what’s the point of getting vaccinated at all? And is there really any value to a booster dose if I’ve had two Pfizer/Moderna or a shot of J&J? My observations: 🧵

How's NHS doing at moment in relation to omicron and other pressures? New thread based on latest data. Note that we prefer to use numbers of covid-19 patients in hospital, rather than new admissions, as two days more up to date and better represents whole picture...1/19

So far we've seen reduction in Omicron clinical severity vs Delta, reflecting both immunity wall and instrinsic virus properties, in 2 different populations: Gauteng, South Africa 73% papers.ssrn.com/sol3/papers.cf… UK 60-70% assets.publishing.service.gov.uk/government/upl…

Some thoughts from seeing a ton of Covid in the ER this week Good news: Aside from a few patients with compromised immune systems, didn't have to hospitalize anyone who was vaxxed/boosted Bad news: Health systems are stressed to the max We need to adapt...quickly Thread👇

London, UK #Omicron update (10 Jan 2022): On 18 Dec 2021, SAGE warned that should the UK persist with plan B, it could see 600-6,000 deaths per day. This is 0.9-9.0 deaths/100k. London appears to have peaked at a level of 0.17 deaths/100k. data source: coronavirus.data.gov.uk

How do hospital admissions of children from #COVID19 in England compare to other infections ? All admissions testing positive for #COVID19 in <18yrs after nearly 2yrs of pandemic: 15,273 Mean annual admissions for Viral wheeze: 77,488 Bronchiolitis: 51,655 Otitis media: 33,000

All this "with Covid" and not "of Covid" talk is nonsense. You won't hear doctors who actually see patients say: "it's just with Covid, no big deal." We know what's going on. We are in the hospitals.

This is how good the epidemiologists have been... spectator.co.uk/article/how-di…

The fact that England managed to restrain from imposing restrictions over Christmas against the advice of activist scientists and the Labour Party, was a decision of global consequence:

Delighted to be giving the next #globalimmuno talk - on effector gd T cell differentiation - Wed 26th Jan at 5 pm GMT/ 6 pm CET/ 12 noon EST. Zoom details Global Immunotalks.

A beautiful cake by senior lab member Anita Gomes for a double celebration: 15th job anniversary of our lab manager, Natacha Sousa; and my own promotion to Full Professor @medicina_lisboa :))

Congrats to lab members Sofia Mensurado and Daniel Inacio for their poster and oral presentation awards at the Annual Meeting of the Portuguese Society for Immunology (SPI)! :))

Celebrating my promotion to professor

I’ve been working in the Blizard Institute for 12 years, but today is my first day as Professor of Bioengineering! Big thanks to all the past and present members of the team and looking forward to more exciting research ahead.

No evidence that infection pre-Omicron variants interferes with immunity to Omicron. On the contrary, immunity is better with more infections. Just like one would expect. Immune Imprinting and Protection against Repeat Reinfection with SARS-CoV-2 | NEJM nejm.org/doi/full/10.10…

We're recruiting!! Fantastic opportunity for a new Clinical Senior Lecturer in Metabolism working in liver, diabetes or related specialties to grow research in London's exciting East End. Visit tinyurl.com/2p84u6n4 or contact me. Blizard Institute Barts Hepatology Diabetes Research @ Barts and QMUL