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Our latest manuscript, “Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome,” is now published at BioRxiv. biorxiv.org/content/10.110…

Out today in Science Magazine, the Tabula Sapiens is 1 of 4 new open-access cross-tissue human cell atlases. This is a major milestone for #singlecell biology, giving us a deeper understanding of the human body and the diseases that afflict it. bit.ly/3FFbMsZ

Please read our latest work from Shigeki out now in Journal of Clinical Investigation: Inactivating genetic alteration of mRNA splicing factor RBM10 co-occuring with mutant EGFR limits EGFR inhibitor response in lung cancer jci.org/articles/view/…

ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. sciencedirect.com/science/articl…

Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation | NEJM nejm.org/doi/full/10.10…

Making a splash on the cover of Cancer Discovery – a characterization of our structurally novel, experimental covalent KRASG12C inhibitor, with updates on studies to date investigating the drug as a potential monotherapy and in combination with a SHP2 inhibitor aacrjournals.org/cancerdiscover…

Fun day of hiking at the Bivona Lab! Good luck to Dora and Daniel Lucas Kerr for the next step in their promising careers 😀❤️

Please checkout the updated version of our preprint, a result of a great collaboration with ⁦Bivona Lab @HarrisLabUMN with my mentors Charles Swanton and⁩ Julian Downward. Work done The Francis Crick Institute Swanton Lab #Downwardlab biorxiv.org/content/10.110…

I am thrilled to share our recent publication in nature, on the Structure of the SHOC2:PP1C:RAS complex, unraveling a lingering 20 year old mystery in the most mutated oncogenic pathway in all cancers. nature.com/articles/s4158…

Join us in welcoming our incoming class of 2022! 💜💛 #mstp #mdphd #doubledocs #uw #universityofwashington

Our study on single-nucleus and spatial profiling of pancreatic cancer was published today Nature Genetics and will be the cover story in the August issue: tinyurl.com/2eac6tnv.

Excited to share how #cancer cells can reprogram the resistance mechanisms similar to that of #bacteria. aacrjournals.org/cancerdiscover…

I am highly honored to have been selected for this prestigious grant by the Damon Runyon Cancer Research Foundation . For me, this is truly a career-changing opportunity. I would also like to express my sincere gratitude to Trever for his great mentorship!

Check out our abstract and poster EP08.02-217 Grateful for my mentor Collin Blakely MD, PhD , teammates Daniel Lucas Kerr and advocates AnnabelleGurwitch IASLC

A groundbreaking work from Revolution Medicine - molecular glues that disrupt native PPIs in KRas signaling. Indeed this is an exciting era for small molecule drug discovery. science.org/doi/10.1126/sc…

Our latest paper is out now in Orli Bahcall! We investigate how APOBEC3B affects EGFR mutant non-small cell lung cancer evolution, from tumor initiation to targeted therapy resistance. nature.com/articles/s4158…

Very proud to have this work finally out in Orli Bahcall! This was a wonderful team effort; I would like to thank Manasi Mayekar and Bivona Lab. It was a privilege to work with our collaborators Debbie Caswell and Charles Swanton from The Francis Crick Institute!

I am excited to announce the publication of our manuscript out today, with Philippe Gui, Charles Swanton, Swanton Lab, Bivona Lab, @Downwardlab, and The Harris Lab! 🧵 1/15 nature.com/articles/s4158…

Pleased to report the results of our clinical trial: Neoadjuvant Osimertinib for the Treatment of Stage I-IIIA Epidermal Growth Factor Receptor–Mutated Non–Small Cell Lung #JCO #EGFR ascopubs.org/doi/10.1200/JC… Thank you to all of the patients who participated.

Today out in bioRxiv we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with Jay Shendure's lab. biorxiv.org/content/10.110…