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A couple of years ago I thought it might be fun to start the week with a tweet about some aspect of trial, or related, methodology - tagged #MethodologyMonday. 100 topics later, I hope you have found some of them useful. Here is a list of the topics so far 1/2

An hour of vigorous exercise in the evening improved sleep quality but left participants feeling less rested—likely due to the body’s recovery process This could explain why some feel they sleep poorly after working out, even with better sleep quality 🛌💤

This review presents the intrinsic physiological and metabolic processes governed by circadian biology and highlights their connection to human performance across different times of the day.

CBT for insomnia showed large effect sizes for reducing severity of insomnia but little effect on pain intensity. Underpins the need to integrate sleep interventions within a multidimensional framework. sciencedirect.com/science/articl…

If are part of the patients/people/public in research community you probably know about PxP. If you don't, might I encourage you to check it out? I feel you will get value from the community. #PatientLed

Dear X Friends, should we add #sleep management to pain management 4 chronic #spinal #pain + #insomnia? Yes, we should! Very large effects on insomnia severity, sleep quality & depressive symptoms, maintained 1y after treatment! JAMA Network Open 🔓 jamanetwork.com/journals/jaman…

Just published introduction to network meta-analysis tells you what it is, how it is done, and how to use it for decision-making – including public health decision-making. pubmed.ncbi.nlm.nih.gov/39108176/

🚨 New study out highlighting the power of small combined changes in sleep, activity & nutrition! A 10% lower risk of mortality was possible with just: ✅ + 15 min sleep/day ✅ + 1.6 min moderate-to-vigorous exercise/day ✅ + ½ serving vegetables/day 📎doi.org/10.1186/s12916…

Women with chronic conditions such as MS are more likely to lose mobility due to poor sleep quality. U-M's Daniel Whibley explains what to watch for—and how this can be treated. michmed.org/zgvX3

✔️ Those who get 7-9 hours of sleep are significantly more likely to thrive. ✔️ Good sleep is linked to increased happiness, productivity, and belief in achieving goals. Check out the poll: thensf.org/sleep-in-ameri…

A new meta-analysis on the impact of goal setting on performance found: 1. Process goals had a large effect on performance 2. Performance goals had a moderate effect 3. Outcome goals had a negligible effect

HOWZAT!! Blown away by this paper! 🌟 It dives deep into spinal DH neurons' roles in pain processing. From intrinsic properties to chronic pain changes, this review is a must-read! 🧠🔬 #Neuroscience #PainResearch #Electrophysiology frontiersin.org/journals/cellu…

CONSORT 2025 Statement Updated Guideline for Reporting Randomized Trials jamanetwork.com/journals/jama/…

Daily movement may not feel like exercise — but it matters more than you think. New data from 24,000+ non-exercisers shows: - Just 4–5 min/day of vigorous activity - Or ~24 min/day of moderate activity Was enough to cut the risk of cardiovascular events (including deaths) by

A recent study of more than 14,000 WHOOP users finds that exercising as close as 4 hours to bedtime can tank your sleep quality. For example: A maximal-intensity workout ending 2 hours before sleep delayed sleep onset by 36 minutes and reduced sleep duration by 22 minutes.

The big sample size doesn't negate the impact of confounding, especially given that it's free living data. Many people may exercise later in the day due to a busier work schedule, less free time etc, all of which can also impact sleep. We shouldn't assume causation with such data

This week saw the publication of SPIRIT 2025, a major update to the international SPIRIT Statement which provides guidance on what should be included in a trial protocol. 1/6 #MethodologyMonday #117

Fibromyalgia is an umbrella terms for a cluster of signs and symptoms where the underlying mechanism(s) can differ between individuals. Hence there is no "best" exercise. These studies ask the wrong question. sciencedirect.com/science/articl…

The greatest threat to your joints isn’t movement—it’s stillness. Cartilage needs load. Muscles need tension. Bones need impact. I’ve seen what happens when people stop. Pain increases. Confidence fades. Recovery becomes harder. Your world becomes smaller. Motion isn’t just

What single intervention can recalibrate your circadian timing system? ⏰ Aric A. Prather, PhD emphasizes anchoring wake time across all days, including weekends. This consistent sleep termination synchronizes your suprachiasmatic nucleus while simultaneously initiating adenosine