Great talk from Carl McCombe 🌿 at the #ECPM2022!

Finally got some crystals that diffract like bombs! New effector structures coming soon

Really great to be able to share this story! Check out our other Tox3 related story (Tox3-PR1) that I didn’t get to share - doi.org/10.1111/nph.17… and how to better make your disulfide bonded effector - doi.org/10.1094/MPMI-0…

I’m seeing an interesting “veiny” phenotype in my tomato leaves after treatment with a protein. Long shot but any plant experts know what this is? 🤔

Where are all the big loops at? #crystallography

Cool to see the diversity of the FOLD effectors!

Please RT: Applications for a Massey University Doctoral Scholarship open on Feb 1. If you have a grade average of A- or better and are interested in the functional characterization of fungal effector proteins, please DM me to see if you should apply! 1/2 massey.ac.nz/study/scholars…

Finally got around to playing with #blender3d. Here is the first effector structure I ever solved (pdb: 7t6a). Massive thanks to Sarah Piper and Dr Emily Furlong for the blender workshop!

I had a great time visiting UC Davis after #2023ISMPMI. Big thanks to Gitta Coaker and Yi-Chang Sung for hosting! Can’t wait to visit again!

Please RT! 🎉 Excited to be starting a joint appointment Biology at ANU ourANU 🎊- will be looking for a lovely #StructuralBiologist to join our lab. If you are interested in infectious diseases, nanobodies and have trail runnjng suggestions, please reach out! 🦙 🦙 Canberra Protein Group

What a nice surprise! Was just about to bin this tray #crystallography

Please RT! 🦙 🦙 Incredible opportunity to establish a Nanobody Facility ourANU Biomolecular Resource Facility - ANU - if passionate about getting the world to use wonderful single domain antibodies PLEASE APPLY! Technical Officer (Nanobody Facility) - Canberra Australia jobs.anu.edu.au/jobs/technical…

Our new preprint is out! Alphafold2 couldn’t do it so we solved the structure of the Pgt effector AvrSr27! 🔥Spoiler: it’s got a novel zinc bound fold important for recognition by Sr27! Thanks to all the co-authors for making this happen! 🌿

Please spread the word! This year’s Stromlo Plant Pathology Meeting will be held in beautiful Queenstown, New Zealand, on Aug 31-Sep 01 (queenstownresearchweek.org/plant-microbe-…)! Queenstown at that time of year is simply amazing, with lots to do: queenstownnz.co.nz 1/2

AvrSr27 is a zinc-bound effector with a modular structure important for immune recognition 📖ow.ly/BAHl50REa2U by Outram et al. @WileyPlantSci #PlantScience

Pls RT! We have a funded #PhD position for UK students available Durham BioSciences. If you're interested in protein design and the idea of making molecular machines get in touch and join us at the new Centre for Programmable Biological Matter Durham University! shorturl.at/TF0Gg

Finally, our preprint on revisiting the evolution and function of NIP2 paralogs in the Rhynchosporium is out. Thanks to Megan McDonald @petersolomon99 and everyone who was involved in this project :) biorxiv.org/content/10.110…

😀 Thanks to Reynaldi D. for his hard work on his PhD project, here he explores the diversity of the NIP2 paralog family and challenges a long-standing result that this effector induces necrosis, an important example of a negative result worthy of publishing