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📌Physician perceptions, attitudes, & strategies towards implementing #GDMT💊 in #HeartFailure with reduced ejection fraction. A survey of the #HFA of the European Society of Cardiology #HFrEF #HF #CardioEd

See the pooled results of PIONEER-HF and PARAGLIDE-HF trial assessing safety and efficacy of sacubitril/valsartan following a worsening HF event across the spectrum of EF. bit.ly/3x8Sc8w #JACC #HeartFailure #LVEF Robert Mentz, MD Shelley Zieroth Kavita Sharma scottdavidsolomon

🔴 Eligibility and Projected Benefits of Rapid Initiation of Quadruple Medical Therapy for Newly Diagnosed Heart Failure JACC Journals jacc.org/doi/10.1016/j.… #medical #MedEd #cardiology #CardioTwitter #CVD #CardioEd #medtwitter #CardioEd

Moving toward a comprehensive geriatric assessment and away from chronological age when envisioning TAVI in older adults: a must-read review in JACC: Advances jacc.org/doi/10.1016/j.… JACC Journals

SGLT2is increase risk of genital mycotic infection but not #UTI. Withdrawal of #SGLT2i led to adverse outcomes in #heartfailure. SGLT2i should be continued along with treatment for mild-moderate UTI/GMI. bit.ly/3U4K3cX (2/2) #JACC Mark Kittipibul MD Robert Mentz, MD

🚨Stunning!🚨 REVERSAL in the decline of heart failure ☠️ in the US 1999-2021 1999-2005 ⬇️ ☠️ 2005-2012 ⬇️ ☠️ 2012-2019 ⬆️ ☠️ 2019-2021 ⬆️⬆️☠️ Age-adjusted HF related ☠️ rates higher in 2021 vs 1999! WT😱🆘 jamanetwork.com/journals/jamac… JAMA Cardiology Marat Fudim, MD MHS

1/3 Check out this editorial with Marat Fudim, MD MHS in EJHF on GDMT & polypharmacy in HFpEF (doi.org/10.1002/ejhf.3…) Original paper: post hoc analysis of PARAGON-HF (doi.org/10.1002/ejhf.3…) EJHF Editor-in-Chief European Society of Cardiology Journals

JAMA Guide to Statistics and Methods article discusses accounting for competing risks in clinical research. #CausalInference #MedTwitter #MedStats ja.ma/3KijGfc

Eric Widera, MD This might make your head explode 90% of the US population is now labeled as having cardiovascular, kidney, and metabolic (CKM) syndrome stage 1 or higher in this JAMA piece I'm penning a letter to JAMA that says 100% have pre-death you in? jamanetwork.com/journals/jama/…

Viewpoint: Ali Abbasi, Lesley Curtis, and Dr. Robert M. Califf discuss how pragmatic clinical research can help in evaluation of new technologies, benefit research sites in underresourced settings, and better inform regulatory decisions and clinical practice. ja.ma/4aOFslk

JAMA Senior Editor Derek Angus of University of Pittsburgh joins JAMA Editor in Chief Kirsten Bibbins-Domingo to discuss "The Integration of Clinical Trials With the Practice of Medicine: Repairing a House Divided." Hosted on AMA Ed Hub™. ja.ma/456Apf3

Our viewpoint now in EHJ: A new framework to overcome the limitations of the "unsatisfactory MACE endpoint". The composite outcome of survival and improved quality of life - what pts want - will be tested in the RECHARGE trial of PCI v CABG in 1200 women and minority group pts.

🔥 A new therapeutic era in #HFpEF #FINEARTSHF with definitive evidence supporting the role of the non-steroidal MRA finerenone at #ESCCongress Now in NEJM nejm.org/doi/full/10.10…

2024 Lasker-DeBakey Clinical Medical Research Award winner Lotte Bjerre Knudsen describes her discovery of GLP-1 for the development of therapies to treat patients with obesity. ja.ma/3TAp1TU #Lasker2024

Back from #WHFEL 2024 seminar; straight on call but energised! A special week: the 10th cohort;the first time we have combined with the Leadership& Advocacy programme; & the end of my 6-year stint leading the programme with the amazing World Heart Federation team. An absolute privilege🙏🏽

Modern RCTs of GDMT in #HFpEF have been well represented with older adults (median age >70y) who carry a high burden of #frailty (upper range of FI>0.50) Reassuringly, evidence supports that frail older adults benefit similarly (or even to a greater degree!) from core #GDMT👇🏾

Should polypharmacy in older adults dissuade treatment optimization in heart failure? No. Contrary to common clinical beliefs, randomized data of core #GDMT suggests efficacy is greater, not lesser, among those on a large # of background medicines. 👇🏾

No longer a disease of failure; after 100 years of tireless breakthrough science, HF is about function. Clyde Yancy, MD, MSc ahajournals.org/doi/full/10.11…

#obesity in pts with #heartfailure: a common challenge and a therapeutic target in HFpEF. Do not miss our #ESC_HFA Scientific Statement on the topic! onlinelibrary.wiley.com/doi/10.1002/ej… EJHF Editor-in-Chief HFAPresident Henry Han Antonio Cannata' Marco Metra Mark Petrie European Society of Cardiology European Society of Cardiology Journals

🚨 Out now in Circulation Research 🚨 So proud with Maria Kontaridis to launch this Compendium on Interorgan Crosstalk in Heart Failure & Cardiometabolic Disease. Heart failure it’s systemic. Multiorgan. Dynamic. Circulation Research DZHK Germany Deutsches Herzzentrum der Charité Max Delbrück Center