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Time to get the disordered protein field a bit more ordered! We propose guidelines on how to describe IDP experiments to better serve experimental researchers, computational biologists, and database/method developers. This was a fun community wide effort led by Short Linear Motif team

Minimum Information About Disorder Experiments (MIADE) guidelines provide community recommendations on the minimum information that should be reported with experiments that structurally characterize intrinsically disordered proteins or regions. Short Linear Motif team nature.com/articles/s4159…

Our resources (ProViz, PSSMSearch, SLiMSearch, xProtCAS, etc) will be down for a couple of days for updates to the server. Sorry if anyone is in need of some summer motif hunting. But hopefully most of you are on holidays.

The servers are all back online after their little summer holiday. Everything has been upgraded and there may be a few issues so let us know if you see anything odd.

Latest screen exploring how #disease-associated #SNVs in IDRs affect SLiM-based #protein-protein #interactions is now up on bioRxiv. Another fun collaboration with the @Ivarssonlab/Jakob Nilsson labs driven by the amazing team of Johanna and Leandro. disq.us/t/4j32bsx

We have an open PhD position applying mass spectrometry-based approaches to peptide interactomics for motif discovery. It's an exciting interdisciplinary project with the Choudhary lab for someone with a strong computational background. Details here: icr.ac.uk/studying-and-t…

Cool work from Julien Duxin on Pol Kappa. Happy that my lab together with Short Linear Motif team could contribute with base editing screening in cells. Catalytic and non-catalytic functions of DNA polymerase kappa in translesion DNA synthesis biorxiv.org/content/10.110…

Our new paper with the @Ivarssonlab & Jakob Nilsson teams characterising mutations in intrinsically disordered regions on a proteome-wide scale! We show numerous examples of disease-causing SNVs making and breaking SLiMs in work driven by Johanna Kliche. embopress.org/doi/full/10.10…

Excited to present a new docking motif for IKK (Inhibitor of κB (IκB) kinase)! A great collaboration with the Zanier lab at the ESBS showed a YDDΦxΦ motif in IκBα, IκBβ and p100 recruits IKK. nature.com/articles/s4146…

Great collaboration with the Short Linear Motif team on defining short linear motifs required for cell fitness using base editor screens. Hundreds of novel functional SLiMs to explore! A proteome-wide dependency map of protein interaction motifs biorxiv.org/content/10.110…

Have you ever wondered how many of the human SLiMs are required for cell viability? We mutated them all to find out in another extremely fun collaboration with the Jakob Nilsson group. The results are now on bioRxiv biorxiv.org/content/10.110…. Check it out!

Congratulations to Ifigenia Tsitsa and Iza on the publication of CompariPSSM - a PSSM–PSSM comparison tool for motif-binding determinant analysis. This part of Ifigenia's her recently completed PhD work and her first first author paper. Check it out here: academic.oup.com/bioinformatics…

SIMBA, a novel quantitative intracellular peptide binding assay, is now on BioRxiv. It excels at saturation mutagenesis studies to define SLiM-binding determinants. This collaboration with the Pryciak group at UMass is the first of many, so keep a look out biorxiv.org/content/10.110…