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Don't miss this week's issue of #ScienceTranslationalMedicine! An adjuvanted mRNA vaccine for COVID-19 extends protection in aged mice, a Viewpoint discusses how to boost vaccine thermotolerance to tackle global vaccine inequity, and more. scim.ag/7MB

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An mRNA #adjuvant that encodes #IL12 amplifies and prolongs immunity from the Pfizer #COVID19 vaccine in aged mice, and features a multiorgan protection sequence that restricts expression to targeted tissues. Dr. David J. Dowling, Ph.D. Byron Brook Precision Vaccines Program scim.ag/7U8

Adding mRNA that encodes immune protein IL-12 to an mRNA #COVID19 vaccine raised vaccine immune responses in aged mice to levels akin to those in younger mice, #NIAID-funded researchers report. Learn more: science.org/doi/10.1126/sc… #NIH #science #research #immunology Science Translational Medicine

What’s next for the development of mRNA vaccines? Researchers at HMS and Boston Children's are working on technologies that could make them more potent, last longer, and have fewer side effects bit.ly/3LQorx4

Building on the success of lipid nanoparticle mRNA vaccines in the recent SARS-CoV-2 pandemic, Brook and Duval et al. addressed waning immunity and durability in older adults. bit.ly/3LXSFOW  Boston Children's Harvard Medical School  Dr. David J. Dowling, Ph.D.

PVP, BCH, and BCH TIDO is pleased to announce publication of the MEMPHIS Patent Application! MEMPHIS stands for Modular Evaluation of iMmunogenicity using Multi-Platform Human In vitro Systems and models safety and immunogenicity of adjuvants and vaccines. shorturl.at/pzSz7

Fentanyl vaccine created in Texas heads for clinical trials, with goal of saving lives dallasnews.com/news/2024/09/0…

#NIAID & its partners highlight the potential of pediatric #vaccine adjuvants, which are vaccine ingredients that can enhance the immune response. The authors summarize opportunities to enhance early-life immunization technology for global use. Learn more: science.org/doi/10.1126/sc…

A new generation of vaccine #adjuvants tailored for the pediatric immune system could help overcome longstanding gaps in the design of #InfectiousDisease vaccines for children, according to a new Viewpoint from researchers at NIAID News. scim.ag/8hu

Scientists are developing a fentanyl vaccine that could chart a new course in the opioid crisis trib.al/bQuqCcV

Out now in iScience journal! Precision Vaccines Program Drs Byron Brook, Soumik Barman, @Dr_Amykacin, Joann Arce, PhD, Dr. David J. Dowling, Ph.D., and Dr. Ofer Levy, MD PhD modeled responses to mRNA vaccine in vitro (outside the body), noting that elders demonstrated impaired BNT162b2 mRNA vaccine-induced Th1 support.