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Let’s start the week in style: just out in Biorxiv one of the most important results from my lab, with the Reinisch lab Yale School of Medicine: “Lipid scrambling is a general feature of protein insertases”. The title pretty much sums it up. Short 🧵(1/13). biorxiv.org/content/10.110…

New work from the Reinisch lab at Yale Cell Biology with the help of Melia Lab and the Burke lab: Spartin-mediated lipid transfer facilitates lipid droplet turnover

Thrilled to see that our story on lipid scrambling by insertases is finally online! It is an amazing collaboration experience with Cristian Cristian Rocha... and Stefano VanniLab !! Yale Cell Biology pnas.org/doi/10.1073/pn…

Happy to share that the work of Cristian Rocha... and Dazhi Li on protein insertases as lipid scramblases (see thread below) is now out in PNAS PNASNews in peer-reviewed form! pnas.org/doi/10.1073/pn…

Cryo-EM Reveals the Mechanochemical Cycle of Reactive Full-length Human Dynein-1 biorxiv.org/content/10.110…

Here’s the big one: In collaboration with Alf Honigmann, Shevchenko Lab, Björn Drobot and Martin Hof we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. biorxiv.org/content/10.110…

2. The work from Sriraksha Srinivasan, Daniel Álvarez and Arun John Peter on identifying lipid binding pocket for lipid transport proteins ( link👇) is out in Journal of Cell Biology! We have added "a lot" of stuff since our preprint. All files and protocols are in Zenodo, give it a try and let us know!

Excited to share our latest preprint, now available on bioRxiv! biorxiv.org/content/10.110… #YaleCellBio #YaleNeuro #PDClab #Lysosome

Lysosome damage triggers acute formation of ER to lysosomes membrane tethers mediated by the bridge-like lipid transport protein VPS13C biorxiv.org/content/10.110…

JIP4 deficiency causes a novel lysosome storage disease arising from impaired cystine efflux biorxiv.org/content/10.110… #biorxiv_cellbio