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Axons or Bust: To Reach Neuron Extremities, RNAs Hitch a Ride on Lysosomes alzforum.org/news/research-… Thank you Alzforum for highlighting our recent study. #NIH #NICHD

Thank you Medical Xpress for highlighting our recent study. #NIH #NICHD Study finds that the transport of mRNAs into axons along with lysosomal vesicles prevents axon degeneration medicalxpress.com/news/2024-05-m…

Thank you, Ingrid Fadelli and medicalexpress.com for covering our work! Study finds that the transport of mRNAs into axons along with lysosomal vesicles prevents axon degeneration medicalxpress.com/news/2024-05-m… via Medical Xpress

Sharing our collaborative work by Salimata Diarra, Chris Grunseich, Kurt Fischbeck, Guida Landouré, Saikat Ghosh and other colleagues: AP2A2 mutation and defective endocytosis in a Malian family with hereditary spastic paraplegia sciencedirect.com/science/articl…

Congratulations for this beautiful work David Gershlick Lab!

Our new paper, in collaboration with the Karolina Skvarova group Univerzita Karlova Fakultní nemocnice v Motole, reveals that patients with the c.269 T>C variant in AP1S1 manifest all symptoms of MEDNIK syndrome, not just enteropathy. 📄 Read it here: rdcu.be/dTW2o.

The AP1S1 c.269 T>C variant causes an L90P substitution in the sigma1A subunit of the clathrin-associated adaptor protein complex AP-1, impairing complex assembly and recognition of dileucine-based sorting signals. @rarediseases

Takami Sho, Li Yu et al. Tsinghua University unveil migratory autolysosome disposal, a response to #lysosome damage where cells expel LAMP1-LC3 positive structures via autolysosome exocytosis, requiring #autophagy machinery, SNARE proteins, and cell #migration. hubs.la/Q02Rwbhg0

Regulation of axonal lysosome transport by BORC a cargo de Raffaella De Pace Raffaella De Pace 🗓️ Miércoles 23 de octubre 🕚 11 h 📍Auditorio Facultad de Ciencias Químicas UNC

Thank you Prof. Cecilia Inés Alvarez and Dr. Victoria Rozés-Salvador for hosting my visit to the CIBICI Facultad de Ciencias Químicas UNC It was such an amazing experience! I loved discussing science with all of you, and meeting the students!

Thanks to the organizing committee of SAN_Neurociencias for inviting me to present during this amazing meeting! It was a blast, with so many interesting conversations and fantastic posters! 🫶🔥

Thanks to the organizing committee of the SAN_Neurociencias for this opportunity! Before, during and after the action with the great Raffaella De Pace! #SAN2024

Thank you for highlighting our work at Division of Intramural Research (DIR) Highlights NICHD News nichd.nih.gov/about/org/dir/…

📅 Lunes 11 de noviembre 10h 📍Auditorio Edificio Integrador Facultad de Ciencias Químicas UNC 🎓 Visitante Distinguido Dr. Juan Bonifacino Juan S. Bonifacino (NIH - 🇺🇸 USA) Conferencia: Descifrando el rol de las cubiertas proteicas en el tráfico intracelular y las enfermedades del neurodesarrollo

Excited to share our latest findings on how the phosphoinositide PI4P pool at the trans-Golgi network (TGN) is regulated through a SYS1-ARFRP1-ARL5-ARMH3-PI4KB pathway, in which ARMH3 (also known as C10orf76) acts as an ARL5 effector to activate PI4KB. rdcu.be/d1dZ2

Kudos to authors Morié Ishida, Adriana Golding, Tal Keren-Kaplan @NICHD_NIH and our collaborators Tamas Balla @NICHD_NIH and Yan Li NINDS! Great teamwork!

“Behind the Paper” commentary on our recent publication Nature Communications demonstrating the regulation of Golgi PI4P and downstream processes by a SYS1–ARFRP1–ARL5–ARMH3–PI4KB axis go.nature.com/4fKotEg

Great paper from @cwilsonrod on the epigenetic regulation of heterochromatin and its impact on neuronal growth. Check it out!🥳

🚨 Exciting postdoc opportunity in Juan S. Bonifacino lab!! If you have a passion for protein trafficking and neurodevelopmental disorders, and want to join a dynamic and collaborative team consider applying! Positions will be available starting in October.🍁🍂