Challenge trials can de-risk product development by providing earlier in-human data for pathogen vaccines and treatments. But use is limited in the US by regulation and unclear approval burdens. Josh Morrison and Alastair Fraser-Urquhart lay out how to fix it. adobe.ly/3WdzTss

Despite the potential to prevent up to 800,000 child deaths from malaria by 2030, Gavi would need to triple its $1.4B malaria vaccine budget to buy and deploy all available doses. Vox covers the latest report from the Center for Global Development & 1Day Sooner:

Gerald Parker will lead the White House Office of Pandemic Preparedness and Response Policy. We're grateful to him for co-hosting our 2024 Operation Warp Speed 2.0 conference at Texas A&M's Scowcroft Institute this past December.

In Africa, where malaria hits hardest, immunisation can make all the difference for children at risk. Losing even one child to this preventable disease is one too many. The urgency is real. Participate in ‘Africa Dialogues: Scaling Malaria Vaccines in a Shifting World,’ to

New preprint finding that eliminating US global health funding over the next fifteen years would cause: - 15.2m deaths from AIDS - 2.2m deaths from TB - 7.9 additional child deaths

This #WorldMalariaDay, tune in to the #AfricaDialogues session hosted by Amref Health Africa to hear how African leaders are scaling malaria vaccines in a shifting world. Follow the link below to register!

A great honor for such a crucial conversation!

On #WorldMalariaDay, we’re reminded that access & affordability of vaccines can mean life or death. 🦟 Malaria caused 249M cases & 608K deaths in 2022 alone. It’s time to embrace this year's theme: "reinvest, reimagine, reignite." 1Day Africa’s Zacharia Kafuko spoke with

“Integrating new tools and vaccines into existing systems is the most cost-effective approach. Creating separate delivery mechanisms only drains resources we don’t have.” - Zacharia Kafuko #WorldMalariaDay2025 #AfricaDialogues #EndMalaria RBM Partnership Amref Health Africa

“It is more cost-effective to integrate new tools and vaccines into already existing structures without needing to reinvent the wheel. Trying to create separate delivery mechanisms, separate timelines, involves money that currently doesn't exist. -Zacharia Kafuko #WorldMalariaDay

We have some exciting new research out from Rafael Dib and Jacob Trefethen! If you’ve ever wanted to invest in vaccine research (and who hasn’t?), read on:

As US FDA faces staffing reductions that threaten US innovation and global health systems that depend on it, Congress has an opportunity with the Prescription Drug User Fee Act reauthorization to invest in the FDA’s workforce and secure the agency's ability to lead. 1Day Sooner

Check out our latest news in our May newsletter: mailchi.mp/1daysooner.org….

Was great meeting with you…

Join us in D.C. for a happy hour on fair compensation in clinical trials! Meet the authors of the new American Journal of Bioethics open letter on ethical pay for participants & connect with changemakers over drinks. Registration link below (1/2).

Come join our team!

Join us for a D.C. happy hour on rethinking clinical trial volunteer compensation! 🧪🍷 We’ll dive into key ideas from an open letter on fairness & payment ethics. Drinks, snacks, & great convo. Registration in 2/2. 🧵(1/2)

Nice NYT article on human challenge trials, featuring 1Day Sooner's advocacy pivot from COVID challenge trials to other diseases like Hep C, and Oscar Delaney's noble choice of volunteering in a malaria challenge trial (and donating his comp!)

🚀 BREAKING: We've launched the first-ever Cooperative Participant Organization (CPO) for clinical trials, connecting academic researchers with motivated healthy volunteers for crucial studies Collaborators: Leiden University, University of Oxford + Malawi Liverpool Wellcome Programme

New Nature Reviews Immunology paper: "Targets of protective immunity & opportunities in hepatitis C virus vaccine development" explores the current landscape of efforts to create a preventative vaccine.