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TRIM21 uses antibodies to degrade invading pathogens, and any cellular protein #TrimAway, inside cells. Amazing! But how? Here is the fascinating mechanism plus new tools for targeted protein degradation! @MRC_LMB Eurico Morais-de-Sá @w_mcewan Mariana Osswald biorxiv.org/cgi/content/sh…

Congratulations to our master student Alif for getting the highest grade for his research project on TRIM21’s role in snake toxin neutralization conducted in collaboration with LMB in Cambridge!

Very happy to have contributed to this work! 😀 if you are interested in fast and cool ways to degrade proteins check out this pre-print.

Dean Clift and Leo James lab define the mechanism that activates the E3 ligase TRIM21 by clustering. This makes TRIM21 a promising component for #optogenetic control of protein degradation by light-induced clustering. We are happy to have contributed! Filipa and Mariana Osswald

Engineered ACE2 receptor traps potently neutralize SARS-CoV-2 biorxiv.org/cgi/content/sh… #bioRxiv

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors biorxiv.org/cgi/content/sh… #bioRxiv

I would recommend this 5 minute read for an introduction to the cytosolic antibody receptor and E3 ubiquiting ligase #TRIM21

A really clever assay here by @Gui_Pap to quantify cell-cell fusion mediated by SARS-CoV-2 spike protein in real time. Led to some interesting findings.... biorxiv.org/content/10.110…

Have you seen us in the paper today? Well done to Mrs Walsh for all her hard work setting up Forest School. Y1 have 💕 their session, Y2 next half term 😁

Do you dream of running a mass-spec facility in an institute with lots of exciting biology and a chance to pursue your own projects? Then dream no more! nature.com/naturecareers/…

Linking optogenetic clustering to degradation and what it tells us about TRIM21 activation. This and much more in this work by @Deanclift1 Leo James @w_mcewan and many collaborators, including Filipa Santos and Mariana Osswald i3S-Instituto de Investigação e Inovação em Saúde

Fresh preprint from the lab on TRIM21 mechanism. More info in @LeoKiss5 tweetorial here:

Latest #Biorxiv paper from our lab looks at how Trim7 interacts with its substrates to explain the diverse roles described for this E3 ligase. Following is a short thread summarising the findings (1) biorxiv.org/content/10.110…… pic.x.com/Izb86yuqSd