
Dean Clift
@deanclift1
@MRC_LMB
ID: 358032931
19-08-2011 08:06:41
26 Tweet
78 Followers
186 Following

TRIM21 uses antibodies to degrade invading pathogens, and any cellular protein #TrimAway, inside cells. Amazing! But how? Here is the fascinating mechanism plus new tools for targeted protein degradation! @MRC_LMB Eurico Morais-de-Sá @w_mcewan Mariana Osswald biorxiv.org/cgi/content/sh…



Dean Clift and Leo James lab define the mechanism that activates the E3 ligase TRIM21 by clustering. This makes TRIM21 a promising component for #optogenetic control of protein degradation by light-induced clustering. We are happy to have contributed! Filipa and Mariana Osswald







Linking optogenetic clustering to degradation and what it tells us about TRIM21 activation. This and much more in this work by @Deanclift1 Leo James @w_mcewan and many collaborators, including Filipa Santos and Mariana Osswald i3S-Instituto de Investigação e Inovação em Saúde

