We are growing!!! Love our biweekly lab meetings and all the cool ideas/collaborations. We are also trying to match Deepak Vadehra’s background game; guess we will get there one day. Watch this space for more 🚀 🔥 Tim Brown, MD MSCE Nicholas Hornstein Udhayvir Grewal Brandon Rose, MD, MPH Sawyer Bawek, DO

💥New paper out! We reanalyzed raw sequencing data from 18,558 standard-of-care Guardant360 ctDNA assays in advanced #colorectalcancer using a partner-agnostic fusion caller. 🧬 Fusions in 1.3% of patients 🧪 93% were subclonal — enriched after EGFR therapy 🔗 Clonal fusions

Another new paper out! Grateful to have been a part of the effort. We (Andrew Pellatt and Arvind Dasari) asked: Can TAS-102 eliminate ctDNA-defined MRD in CRC after adjuvant chemo? 💊 Single-arm phase II study of CRC pts with MRD by ctDNA after curative-intent therapy (Stage

Here’s to new beginnings. Excited for the new chapter and all the wonderful things that are yet to happen. Winship Cancer Institute of Emory University

Drs Udhayvir Grewal and Tim Brown, MD MSCE discuss the evolving treatment of #stmcsm with new targeted agents 🎯like zolbetuximab for #HER2- but #CLDN182+ disease. They describe 4 biomarker (MSI/MMR, HER2, PD-L1, CLDN18.2) profiles that guide therapy #GIonc doi.org/10.1093/oncolo…

Great job by these bright future oncologists.

It was great talking to my colleagues from Nevada and around about updates in upper GI cancers #ASCODirectLV Thank you Total Health | Oncology 📖🔬 for the opportunity. Gut Onc Lab

Had a great time at the We Stand Together Health & Wellness Fair this weekend! Really appreciated the chance to talk with community members about colorectal cancer—so many great questions and conversations. Baptist Health Baptist Health Cancer Care #ColorectalCancer #CancerAwareness

CEA was discovered in 1965. By the 1970s, CEACAM5 was recognized as a hallmark of colorectal cancer. Yet in 2025, CRC still has no approved ADCs. That may change. 🚨 First-in-human data for Precem-TcT (anti-CEACAM5 + exatecan) now in Nature Medicine PROCEADE-CRC-01 dose

Finally published The Oncologist: "Blueprint for creating an #earlyonset #colorectal #cancer program based on experiences from seven clinical centers across the United States and Canada" academic.oup.com/oncolo/article… #earlyonset #colorectal #cancer #cancerresearch Vanderbilt University Medical Center

Proud to have a great team of friends and collaborators. Gut Onc Lab

Hunting for the Very Rare Clonal Fusions for Clinical Benefit - Scott Kopetz oncodaily.com/science/scott-… Nicholas Hornstein #ColorectalCancer #CRC #EGFR #Cancer #OncoDaily #Medicine #Oncology #MedEd #MedX #MedNews

Targeting the YAP-SDC1 axis overcomes resistance to KRASi in GI cancers by blocking SDC1-driven macropinocytosis and RTK activation, offering a promising strategy for KRASi resistance. Wantong Yao Haoqiang Ying Cell Reports Medicine #crcsm To the clinic! pubmed.ncbi.nlm.nih.gov/40713971/

They grow up so fast. From superstar fellow to now superstar junior faculty. Watch out NETs Udhayvir Grewal is on the job. Gut Onc Lab Tim Brown, MD MSCE Nicholas Hornstein

Hot off the presses, probably my favorite interventional paper of 2025 (doesn't hurt that I look up to several of the authors as mentors or role models). 💉RAS vaccination is starting to look less like fantasy, more like reality. 🆕 Nature Medicine | Wainberg et al 🎯

Congratulatios Deepak Vadehra !! This is so amazing! Proud to know you and work with you. This is such important work for the care of young patients with cancer. #AYAsm

I appreciate the shout out from my brothers at Gut Onc Lab. So much work to do , and just thrilled to be able to help contribute to moving the bar forward

Excited to have the one and only Dr. Nina Niu Sanford join us for our lab meeting today. Exciting perspectives on some very cool GI Onc research ideas. Thanks for joining us, sharing your wisdom & offering some solid advice. The team is gearing up for #GI26 but mostly just having fun 🚀

Feel like I’ve felt this way before... Gut Onc Lab Udhayvir Grewal Deepak Vadehra Tim Brown, MD MSCE