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Nice location for learning more about Immunology Australian and New Zealand Society for Immunology

Tangye and Deenick labs dominate in Garvan trivia Stuart Tangye Júlia Bier

Taking a break at the ASI NSW/ACT retreat. Not a bad spot for some Immunology. Australian and New Zealand Society for Immunology

Well done Anthony Lau representing the lab and taking home a prize for his talk on PI3K GOF at the ASI NSW/ACT branch meeting. Fellow Garvinites Gammy and Etienne also taking home prizes. Garvan Institute of Medical Research Australian and New Zealand Society for Immunology

Congrats Julia on handing in your thesis! Well done for all you’ve achieved in your PhD. Júlia Bier Stuart Tangye

Fantastic paper by Shane Grey and Chris Goodnow on how A20 tunes immunity. A20 is mutated in some patients with Behcet's which is endemic along the ancient Silk Road. Is the price of immunity a predisposition to autoimmunity? Garvan Institute of Medical Research Nature Immunology rdcu.be/bRqcC

Another great Deenick Lab graduate Garvan Institute of Medical Research Stuart Tangye

⁦Great talk by ⁦Júlia Bier⁩ from ⁦Deenick Lab⁩ and ⁦Stuart Tangye⁩ Garvan Institute of Medical Research⁩ on APDS syndrome. Using CRISPR mice to dissect the mechanism of immune dysregulation in patients ⁦Australian and New Zealand Society for Immunology⁩ #ASI2019SA.

Rare genetic disease diagnosis doesn’t only help patients and their families – it benefits the wider population too. Stuart Tangye and The Clinical Immunogenomics Research Consortium are delving into DNA to reveal these incredibly uncommon genetic variants medicalresearch.nsw.gov.au/how-rare-disea…

First data from the IUIS IEI/PID c'ttee on COVID19 in PID pts are in. thanks to Isabelle Meyts for summarising • 6 cases reported in PID patients to 22/03, none severe, 3 needing admission. • 1 patient co-infected with another Coronavirus (CoV229E).

A summary of The Clinical Immunogenomics Research Consortium and our blueprint for genomic medicine. Pls see online list of all the amazing CIRCA members. Thanks to St Vincent's Clinic AIFA Jeffrey Modell Foundation (JMF) Garvan Institute of Medical Research Kinghorn Genomics IDFA Stuart Tangye et al. For the patients! rdcu.be/b4AX7

Primary immune deficiency is caused by genetic mutations that lead to immune dysfunction and subsequent susceptibility to infection. Elissa Deenick Garvan Institute of Medical Research et al review the mechanisms underlying defective antibody responses in #PID. #immunology onlinelibrary.wiley.com/doi/10.1111/im…

Another great patient outcome The Clinical Immunogenomics Research Consortium, Kinghorn Genomics and Garvan Institute of Medical Research. CTLA4 haploinsufficiency 2˚ to cryptic splicing presenting with Kaposi sarcoma treated with everolimus. Thx to AIFA St Vincent's Clinic Jeffrey Modell Foundation (JMF) and the patients! link.springer.com/article/10.100…

Congrats Elissa Deenick and Júlia Bier from Garvan Institute of Medical Research cool review describing a new mechanism of autoantibody production by extrafollicular plasmablasts that bypass GC negative selection in PID patients with PI3K GOF. Relevance to AIHA/ITP? onlinelibrary.wiley.com/doi/10.1111/im…

In our latest paper, in Science Immunology, led by Rui Yang 杨睿 from Casanova Lab, we determine the consequences of Tbet deficiency on B cells humoral immunity in humans. science.org/doi/10.1126/sc…

Out today in Journal of Experimental Medicine our Deenick Lab paper comparing APDS1 and APDS2. We show while these two conditions are similar, not all PI3K dysregulation is the same. Great collab with Stuart Tangye and 3 great PhD students Júlia Bier, Tina Nguyen and Anthony Lau bit.ly/42rfmlB

1/ How do you recover microenvironmental signals that drive cell differentiation from sc data? By taking the ENTRAIN! ENTRAIN is an environment-aware trajectory inference tool developed by Wunna Kyaw a brilliant PhD student Garvan Institute of Medical Research UNSW Medicine & Health. tinyurl.com/2vh2273d

Dear Chemo, we need to talk… What if therapies used to control primary tumor growth increase the likelihood of metastatic relapse? And how do they impact disseminated cells that have already seeded distant organs at diagnosis? Why do we need to understand EXTRA-TIME....