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#MT180 Delphine Leclerc Delphine Leclerc Delphine est doctorante Université de Rennes / @CSignaling 📃Sa thèse : Concevoir et mesurer l'efficacité de nouveaux traitements in vitro pour corriger les mutations responsables de maladies génétiques. Portrait : doctorat-bretagne.fr/fr/actualites/…

👏 Félicitations aux 2 lauréats de la finale régionale #MT180 qui représenteront la #Bretagne à la 1/2 finale nationale 🏅 Prix du public : Victor Lauriau 🏅 Prix du jury : Delphine Leclerc Un grand bravo aux doctorantes et doctorants qui ont brillamment relevé le défi ce soir !

#MT180 👏Bravo à toutes et à tous d'avoir relevé le défi avec brio et générosité ! Toutes nos félicitations à Delphine Leclerc qui remporte le prix du jury et Victor Laurio récompensé par le public ▶️Rdv à Paris où Université de Rennes sera doublement représentée lors de la demi-finale !

⏱️ #MT180 ⏱️ C'est parti pour la demi-finale nationale ! 🎉

👏 à Victor et Delphine Leclerc pour la qualité de leurs prestations, respectivement sur la réduction de bruit des lasers DFB à fibre et sur la correction in vitro des mutations responsables de maladies génétiques. Verdict demain ! #MT180

Fin des auditions pour cette demi-finale nationale #MT180 🇨🇵 Place aux délibérations du jury. ✅ Rendez-vous ici, sur notre compte Twitter, demain vendredi à partir de 10h, pour l'annonce des résultats.

A new report in NEJM from Waseem Qasim and coworkers describes the clinical outcomes of the first three T-cell leukemia patients treated with triply base-edited CAR-T cells in the first clinical trial of a base edited therapeutic, conducted at Great Ormond Street Hospital in the

I am thrilled to announce that I have successfully defended my PhD !!!😁🧬🔬 Now, I am ready to embark on a new chapter of my scientific journey by crossing the Atlantic Ocean to join a new laboratory 🇺🇸 and continue my exploration of genome editing tools! Thanks you all! #PhDone

Genetic engineering and accelerated evolution of microbes can help climate change by, for example, decreasing methane production in livestock, offering better fertilizers, improving bioremediation and producing chemicals sustainably go.nature.com/43tQRUC

Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s4158…

Research Briefing "Capturing prime editor off-target sites within the genome" Liang S, Wolfe S. Nat Methods 2023-05-08. doi.org/10.1038/s41592… #CRISPR

🧬The Codon Guide to Synthetic Biology 100+ papers. 11 free courses. 10 books. Plus videos, blogs, journals, books, and everything else that you need to get started in this field. Please send me your feedback and additions! readcodon.com/p/synbio-guide

Identification of 24 proteins with conserved extracellular-vesicle-sorting abilities paves the way for EV-based engineering. #NBThighlight nature.com/articles/s4146…

We’ve always wondered if there was something beyond CRISPR for genome editing. We now report that animals, plants, fungi and viruses have troves of programmable nucleases capable of efficient gene editing in human cells An update on our Fanzor work! science.org/doi/10.1126/sc… 1/7

Delighted to share the first article of the Miller Lab about Next-generation biological vector platforms for in vivo delivery of genome editing agents! Written with Michael Siroky and Shannon Miller sciencedirect.com/science/articl… Thanks to my PI for this opportunity 🙏

1/ 🧵 Thrilled to share work of Eligo Bioscience just published in nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology nature.com/articles/s4158…

Thrilled to see our click editing paper out today in Nature Biotechnology! 🚀 Click Editors (CEs) are a new class of genome writers which combine DNA polymerases and HUH endonucleases with RNA-programmable nickases for precise edits without DNA DSBs🧬✨ nature.com/articles/s4158…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

Excited to share our new system for evolving eVLPs with improved production and protein delivery efficiencies! Grateful to David R. Liu and liugroup for support throughout this study, and special thanks to co-authors Meirui An and Paul Chen for their contributions!

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time