Presented now at #ASH23 by Othman Al-Sawaf: In a phase 2 trial, anti-PD-1 inibitor tislelizumab + next gen BTK inhibitor zanubrutinib had an overall response rate of 58.3% in patients with Richter's transformation Universität zu Köln Uniklinik Köln #leusm #lymsm #CLL doi.org/10.1038/s41591…

A beautiful wrap-up for this year! Please check out our (pre-proof) review about the role of the tumor microenvironment in CLL pathogenesis. A very nice piece of work from VomSteinA Michael Hallek sciencedirect.com/science/articl…

Please RT and register: West German Lymphoma Symposium ⁦Hämatologie und Stammzelltransplantation, UK-Essen⁩ ⁦⁦Uniklinikum Essen ⁦Medizinische Fakultät Essen ⁦Uni Duisburg-Essen @unidue.bsky.social⁩ DGHO e. V.⁩ #sfb1530 lymphoma-symposium.de

A great way to close the #ESHCLL2024 Day1: a friendly get together, Mentored Poster Walks & informal scientific exchange between colleagues & friends. Thank you to all Poster Presenters & to H. Nguyen Elisa ten Hacken Carsten Niemann & A. Rawstron for your mentorship! #ESHCONFERENCES

And a special thanks to Fabrizio Mavilia and VomSteinA #ESHYOUNGREPORTERS, for lively reporting this conference from a scientific perspective! #ESHCLL2024 #ESHCONFERENCES #HAEMATOLOGY #HEMATOLOGY #leusm #CLLsm

📢Open position for Technical Assistant at #IBMG I am looking for the building blocks of my lab at Uni Stuttgart. Interested? please apply here 🤩 stellenwerk.de/stuttgart/jobb… Peltzer Lab Stuttgart Research Center Systems Biology-SRCSB #IBMG #SRCSB #openposition #Technician

Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: kinase-library.mit.edu/home Wonderful collaboration with Cantley Lab Turk Lab YaffeLab. Many years of work led by Jared Johnson! nature.com/articles/s4158…

My huge congratulations to Sumiya, Shaista and Sanjay for this very nice publication!! We are so thankful to be involved and it was so lovely to be able to follow how the challenge of encapsulating hydrophobic drugs such as kinase inhibitors could be tackled elegantly here.

Incredibly proud of our first paper in CDD press on pMLKL-s345 . Congrats Konstantinos k. for driving this project. BIG Thank you to all our collaborators Alessandro Annibaldi Andreas Linkermann Walczak Lab Pardo Galvez Lab for your incredible support and input. nature.com/articles/s4141…

📢Our latest review is online! We discuss how macrophages influence CLL progression and frontline therapy response, a topic initiated and contemplated by our youngest lab member @hjestrabek. Such a great joy for me to work with the new Gen of 2000s 🎉 sciencedirect.com/science/articl…

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma | Science science.org/doi/10.1126/sc…

As promised, the second issue of our CLL review series is out now at Seminars in Hematology. Check it out if you are interested in CLL biology and mouse models! sciencedirect.com/journal/semina…

Great pleasure to present our work on the role of RIPK1 in beta cell survival! Congratulations Önay Veli for this amazing piece of work. Thanks a lot to our collabs especially to Alessandra Kupper Cardozo SFB_1403 CECAD Cologne Universität zu Köln

Excited to share our Richard Lewis Michael Hallek perspective on double-refractory (2R) #CLL, now in Blood Journal. 2R pts are a growing challenge with poor outcomes. We outline the current landscape and explore targets in the tumor microenvironment. #CLL doi.org/10.1182/blood.…

Beyond excited that the first paper of my PhD journey is out in SNO today, reviewing the brain metastatic immune microenvironment. Super grateful for the great collaborative effort, particularly the guidance of Hien Nguyen and Roland Goldbrunner ! academic.oup.com/neuro-oncology…

🆕🆕🆕Preprint from our labs doi.org/10.1101/2025.0… In this brief report, we evaluated various macrophage coculture systems for their CLL-feeding potential, phagocytosis capacity, induction of treatment resistance, and their impact on the transcriptional profiles of CLL cells

Time for a quick read? Check out our perspective on TiME interactions in CLL and RT! Fun discussions with Phuong-Hien Nguyen and Alex Vom-Stein! frontiersin.org/articles/10.33…