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🦠Clinical case about #infections 👉39-year-old👩with #SLE and #APS 💊previous #CTX, current #HCQ & #methylprednisolone 16 mg/day 🤒episodes of persistent #fever ⏭️recurrent non-tuberculous mycobacterial infections 💡What's your clue about the cause? 📢RT this challenge!

Journal Impact Factor (JCR 2023, Web of Science) of top journals in #Rheumatology. Gentle reminder: JIF shall not be used to assess the quality of individual publications💡 #RheumTwitter

BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

CONGRESS #ACR23 | Dionysis Nikolopoulos, Karolinska Institutet, discussed impact of neuropsychiatric #SLE on HRQoL in 2968 pts with SLE from 4 ph-III trials (BLISS-52, BLISS-76, BLISS-SC & EMBRACE). Pts with NPSLE had significantly lower SF-36 PCS (35.7 vs 39.6) & MCS scores (37.3 vs 41.4),

An eye-opener! Absolutely worth reading. A wonderful collaboration with Jinoos Yazdany THEE Ashira Blazer MD @CMLanataMD Dionysis Nikolopoulos ‼️ Spread the news! 🔔

«Με πήραν κάποιοι γονείς τηλέφωνο οι οποίοι ξέρετε δεν είναι από τους γονείς οι οποίοι για τους δικούς τους λόγους θέλουν να έχουν βήμα, προβολή...». Μιλάμε για άνιωθο τομάρι. Φτου σου ξεφτίλα. #τεμπη_εγκλημα

🚩SLE-APS is associated with a less profound IFN-signature within the SLE population 🚩Distinct transcriptomic profiles characterise venous and arterial thrombotic events in SLE-APS. ard.bmj.com/content/early/…

Disentangling the riddle of #SLE with #APS Blood transcriptome analysis reveals a less pronounced IFN-signature and distinct molecular profiles in venous versus arterial events 🔬 Whole-blood RNA-sequencing ⭐ 299 SLE (108 SLE-aPL+) ⭐72 matched HC 👉 bit.ly/3PWPgCb

Wha is the role of monocyte heterogeneity in #lupus? ▶️ subset-specific epigenetic and transcriptomic programmes identified ▶️ association with disease activity ▶️ lupus-specific subsets with distinctive functions revealed (complement and IFN related) 🔗 bit.ly/4d6NPuW

🇮🇹The first paper of the Italian Registry of #pregnancy in #rheumaticdiseases is out!🤰 Cannot express enough gratitude & pride to 🙏outstanding investigators collecting data since 2018 🙏SIR - Società Italiana di Reumatologia for the support 🙏>1000 patients for participating rmdopen.bmj.com/content/10/2/e…

🆕 What's the role of #stromalcells in the #pathogenesis of #GCA?🔥 🔴 Inflammatory events activate ineffective #repair mechanisms 🔲 Dysfunctional #smoothmusclecells & #fibroblasts phenotypically shift along their lineage and colonise the #intima 🔗 bit.ly/49X3OZP

🎯 A novel #biomarker for #SystemicSclerosis: anti-protein arginine methyltransferase 5 (PRMT5) antibody 👫 prediction of #skin & #lung involvement. 🐁 immunisation with recombinant protein PRMT5 induced SSc-like manifestations 🔗 bit.ly/3Qrnnmm

Post-PEXIVAS, still controversy about plasma exchange in ANCA-assoc vasculitis. Guidelines recommend against routine use, no clear benefit in subgroup analysis, KenWarringtonMD tells #ARANZRA24 that Mayo Clinic have moved away from it. Many good people still use it, though, so…

Congratulations to all winners of the #EMEUNETtop10abstracts at #EULAR2024! Yvonne Tan Dionysis Nikolopoulos Quirine Dumoulin Jack Arnold Tsuneyasu Yoshida🇯🇵→🇺🇸 @m_scherlinger Celina Geiss Shinji Izuka Liubov Petelytska and Blaž Burja Keep following our #EMEUNET socials for updates on each abstract!

🦋 Novel insights into the sex bias in #SLE ♀️ ♂️ X chromosome inactivation (XCI) may contribute to female prevalence 📉 XCI-skew is reduced in SLE compared with HC BUT 📈 XCI patterns of immune cells seem to be modulated by disease activity 🔗 bit.ly/3xrO0Bn

#Interferon and #B-cell Signatures Inform #PrecisionMedicine in #Lupus Nephritis 💡Druggable pathways by #lupusnephritis transcriptome 💡Drugs benefit differentially depending on disease phase More: pubmed.ncbi.nlm.nih.gov/38899167/ KIReports By Dionysis Nikolopoulos @JuliusLindblom 3TR-IMI

Αστυνομικός βρίζει χυδαία τον ευρωβουλευτή Παππά (όργιο, κερατά, ψωλαρπάχτρα), ο Παππάς απαντάει πολύ πιο ήπια, και η ΝΔ ζητά να διαγραφεί ο Παππάς επειδή έβρισε ΤΟΥΣ αστυνομικούς (γκεμπελική διαστρέβλωση) Δεν είναι πειθαρχικό παράπτωμα αυτό του αστυνομικού;

In the Sept issue ▶️ #APS #SLE by #transcriptomeanalysis 🦋 ❇️ #IFN I-II signature ▶️ highest in SLE-aPL-negative 🔵 Venous ▶️ neutrophils & B cells 🔴 Arterial ▶️ DNA-damage-response & impaired metabolism 🔗 bit.ly/4goyd7R Dionysis Nikolopoulos George Bertsias Ioannis Parodis

Day 1 of the #3TR Annual Meeting is done! ✅ What a fantastic start with insightful presentations, progress updates and breakout sessions! 🙌 We’d also like to thank our host AstraZeneca for making this meeting possible! See you tomorrow for Day 2! #3TR #Gothenburg

Molecular basis for the disease-modifying effects of #belimumab in #lupus: ✅ neutrophil degranulation, type I interferon signalling and cytokine production👉 good response ❌cell cycle checkpoints, PI3K/Akt and TGF-beta signalling pathways👉bad response ard.bmj.com/content/early/…