🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

Joshua Crapser's article exposes how the brain's extracellular matrix (ECM)—a massive 20% of its volume—is the hidden key to combating brain aging and neurodegeneration! 🧠🚀 It's time to shift focus and unlock new therapies! #Neuroscience #BrainHealth #Aging

A seminal work uncovering how "Pathogenic hypothalamic extracellular matrix promotes metabolic disease" pubmed.ncbi.nlm.nih.gov/39294371/

Nature News & Views highlights the obesity mechanisms driven by a build-up of molecular mesh around hunger neurons nature.com/articles/d4158…

Increased levels of extracellular matrix proteins associated with extracellular vesicles from brains of aged mice pubmed.ncbi.nlm.nih.gov/39377264/

Extracellular matrix integrity regulates GABAergic plasticity in the hippocampus pubmed.ncbi.nlm.nih.gov/39491759/

Microglia phagocytosis of PNNs mediates PV-positive interneuron dysfunction and associated gamma oscillations in neuroinflammation induced model of cognitive impairment in mice pubmed.ncbi.nlm.nih.gov/39489286/

Macrophages producing chondroitin sulfate proteoglycan-4 induce neuro-cardiac junction impairment in Duchenne muscular dystrophy pubmed.ncbi.nlm.nih.gov/39523812/

Eleven clinical trials that will shape medicine in 2025 nature.com/articles/s4159…

FN1 and VEGFA Are Potential Therapeutic Targets in Glioblastoma as Determined by Bioinformatics Analysis pubmed.ncbi.nlm.nih.gov/39730176/

Adolescent cerebellar nuclei manipulation alters reversal learning and perineuronal net intensity pubmed.ncbi.nlm.nih.gov/39753302/

Disruption of extracellular matrix and perineuronal nets modulates extracellular space volume and geometry pubmed.ncbi.nlm.nih.gov/39753300/

Matrix Biology published our study on "Neurocan regulates axon initial segment organization and neuronal activity" pubmed.ncbi.nlm.nih.gov/39788215/

Pro-cognitive reshaping of neuronal dynamics by a human CSF-based factor pubmed.ncbi.nlm.nih.gov/39763806/

A new study from our group is online: Partial microglial depletion improves synaptic plasticity and cognitive performance in aged mice sciencedirect.com/science/articl…

Matrix metalloproteinases accelerate pericellular matrix breakdown and disrupt mechanotransduction in osteoarthritis pubmed.ncbi.nlm.nih.gov/39956307/

Dr. Carla Cangalaya from our group got Marie Skłodowska-Curie postdoctoral fellowship to move for 2 years to Dr. Christos Gkogkas lab at the Foundation for Research and Technology (FORTH) in Greece and study synaptic pruning by microglia in neurodevelopmental diseases.

A preprint of our new study showing that Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits is available in BioRxiv: doi.org/10.1101/2025.0…

This year, there were two symposia on ECM at the German Society for Neuroscience. A lot of new data was shown, such a memorable event! nwg-goettingen.de/2025/default.a…

Astrocyte-derived MMP-9 is a key mediator of pseudorabies virus penetration of the blood-brain barrier and tight junction disruption pubmed.ncbi.nlm.nih.gov/40176142/

Our article in Alzheimer's & Dementia on treatment of tauopathies received enough views to be a Top Viewed Article - onlinelibrary.wiley.com/doi/full/10.10… #TopViewedArticle Wiley in research