Robert Brodsky ushers in a paradigm shift in our understanding of #aHUS #TMA. Plus tools to functionally evaluate #complement in other disorders. USTMA Alliance and Consortium aHUS Alliance Action Complement Kidney TMA UK Complement Society

Today marks my last day as a Heme fellow on the Hopkins Heme Consult service! Can’t believe how this year has flown by! ⁦Robert Brodsky⁩ ⁦Johns Hopkins Hematology⁩

Out in Blood (first edition). Thx to reviewers who encouraged us to prove classical pathway stimulus on multiple cell surfaces including endothelial cells (HMEC1) shown below. Commercialization coming!

Most powerful diagnostic and monitoring assay for aHUS/CM-TMA now available. #ASH24 Can also monitor any complement inhibitors used for PNH, M. Gravis, CAD etc.

Introducing mHam 2.0 Podcast on this site is a nice primer for housestaff, fellows and others on complement-based diagnostics and TMAs. mham.machaondiagnostics.com

🚨🎧NEW EPISODE! In this episode, our MD, Dr. Brad Lewis, talks with Dr. Robert Brodsky about a new test he and his lab have recently developed: modified HAM (mHam). Listen here ➡️ bit.ly/3D3kBQ6

Fantastic discussion of sickle cell disease and the potential for cure.#sicklecell #curesicklecell #sicklecellawareness #SCDunstoppable #haplobmt youtu.be/IIuL_7XeY0o

Almost every patient can have a haplo donor available, now we can say this approach is safe and effective for sickle cell disease. While gene therapies are effective too, access and cost (here and globally) will be major issues #bmtsm

The procedure would greatly expand the pool of potential donors, in addition to costing less than one-quarter of the price of innovative gene therapies. Source: Axios search.app/qV26Ke9E6k7qVZ…

Genetic and Epigenetic Dysregulation of CR1 is Associated with Catastrophic Antiphospholipid Syndrome (CAPS) | medRxiv New insight as to what makes (CAPS) catastrophic! Now we may be able to stop it from being catastrophic. nam02.safelinks.protection.outlook.com/?url=https%3A%…

notebooklm.google.com/notebook/b3751… CR1 deficiency and CAPS

Five former ASH presidents in NYC NYAS for great symposium on sickle cell disease. One of them 🙁 still doesn't know how to wear a name tag.ASH

Can u stop thrombosis and treat CAPS without anticoagulation? CR1 and #complement. Great work Nikhil Ranjan. sciencedirect.com/science/articl… EULAR American College of Rheumatology Johns Hopkins Rheumatology Hemostasis and Thrombosis Research Society HTRSFellows Blood Journals Portfolio USTMA Alliance and Consortium #MedTwitter