I'm seeing some conflation of terminology around HRR-related gene mutations and the HRD phenotype in prostate cancer. Here's a slide I use to clarify. It matters because several HRR-related gene alterations (e.g. within ATM) do not appear to result in an HRD mutational signature.

Had a really amazing discussion about #PrecisionMedicine with the very wonderful yasmeen rauf! Dr. Rauf, you’re a true #superhero! #sno2022 #PrecisionMedicine #btsm

DYK that GLASS data is accessible through the cBio portal? cbioportal.org/study/summary?…

One of the best sessions from the Neuro-oncology review course this year at #sno2022 by Dr. michael malinzak! Neuro-radiology made engaging and palatable to non-clinical audiences as well!

Clinical implementation of integrated molecular-morphologic risk prediction for #meningioma WHO grade + methylation class + 1p/6q/14q CNV DKFZ #neuropath Is there a need for TERT and CDKN2A? Read more: onlinelibrary.wiley.com/doi/full/10.11…

I meditated 15 hours a day for 6 months straight with one of the toughest Buddhist monks on the planet. Here's what I learned:

A patient presented w/an ill-defined FLAIR hyperintensity/T1 hypointensity in the temporal lobe on MRI and new onset partial seizures. The lesion was resected through a craniotomy. What is your differential dx? #BWHPathCotW #BWHNeuroPathWinter #PathTwitter #Neuropathology 1/

Case contributed by: Dr. Andres Santos (Andres Santos), and Dr. Keith L. Ligon (Keith Ligon). BWH Neuropathology 4/

In the phase III externally controlled trial of autologous tumour lysate-loaded DC vaccination (DCVax-L) vs SoC for newly diagnosed or recurrent glioblastoma demonstrates promising median OS durations & meaningful increases in the tails of the OS curves: jamanetwork.com/journals/jamao…

The genetic and phenotypic spectra of adult genetic leukoencephalopathies in a cohort of 309 patients #neuropath academic.oup.com/brain/advance-…

Towards a single-assay approach: a combined DNA/RNA sequencing panel eliminates diagnostic redundancy and detects clinically-relevant fusions in neuropathology #neuropath actaneurocomms.biomedcentral.com/articles/10.11…

Online Now: Revealing de novo pyrimidine synthesis as a key vulnerability in brain tumors dlvr.it/SdJcgl

Papillary #meningioma (CNS WHO 3) with BAP1 loss by immunohistochemistry. 7/8 of cases signed out as rhabdoid meningioma turned out to be BAP1 retained. Molecular biomarkers are needed to overcome variance in histological interpretation.

Myxopapillary ependymoma from the thoracic spine... the reason why it is a CNS WHO 2 tumour in CNS5. Despite the low-grade histology, some do recur locally and along the neuraxis. One of my case "metastasized" to the temporal lobe and bled out

My thoughts on the phase 3 results of Alzheimer's drug lecanemab from Biogen and Eisai, presented at #CTAD #CTAD22 and published this evening in the NEJM. Major takeaway – this is NOT the breakthrough we have been waiting for. Key points:

1/ People often ask what readings I recommend for clinicians & trainees who want to learn about psychodynamic therapy. Here's a partial list For a bird's eye, jargon-free introduction to psychodynamic thought, read chapters 1 and 2 of "That Was Then, This is Now" by yours truly.

You know English. You don’t know Malayalam. You decide to learn it by listening to podcasts that are purely in Malayalam. What will happen? A thread about language models, meaning, understanding etc…. Plus, you get to learn Malayalam :-) 1/N

1/How do age and anatomical location shape H3-K27M gliomas' intrinsic and extrinsic features❓Very excited to share this work together with Li Jiang, Erik Samuelsson, MatsNilssonLab and Mariella Filbin , published today Nature Genetics❗️rdcu.be/c02lT

What can depersonalisation disorder say about the self? | Aeon Essays aeon.co/essays/what-ca…