Did you know chromosomal loops can repel one another? Did you know that Hi-C maps have a hidden signature that tells you the sizes of chromosomal loops? We came up with a theory that describes interphase chromosomes folded into loops! Check it out! biorxiv.org/content/10.110…

i had a friend who put a frozen burrito in the microwave and when it didn’t heat up she threw the burrito away and tried heating up a different one

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging biorxiv.org/cgi/content/sh… #bioRxiv

Happy to announce that my PhD paper supervised by Jean-Baptiste Sibarita and Rémi Galland is finally out in Frontiers - Bioinformatics and Systems Biology! We performed live spectral single molecule imaging by simply stacking two microscopes on top of each other 😅 frontiersin.org/articles/10.33…

It is insane that while MIT's endowment grew by over $9 BILLION in 2021, nearly 1 in 4 grad students struggle to keep up with cost of living. I say to MIT: invest in your students. I stand in solidarity with MIT Graduate Student Union in their efforts to form a union.

Do you remember the days before same sex marriage when it was a common argument that gay and bi people would render the word ‘marriage’ meaningless, that people would marry their dogs, that incest was next, that we’d groom our victims into marriage to protect underage sodomy? 1/

We Fritzsche M et al combined FRAP and lattice light sheet microscopy to give volumetric context to cellular molecular dynamics doi.org/10.1002/smtd.2… Thanks to hclnyrk Narain Karedla AIC at Janelia Kennedy Institute of Rheumatology Rosalind Franklin Institute @NDORMS University of Oxford MOSAIC Group @ScopeShifu Eric Wait

Preprints are great... in theory. They get science out fast and without paywalls. But what good is a free archive of all scientific knowledge without journals to tell you which papers are worth your time, and without impact factors to tell you who to hire?

Excited to share our latest work revealing a repressive methylation ceiling in EZH2-mutant lymphoma! We made this discovery by finding drug addiction mutations, a strategy we expect to be broadly useful for uncovering new biology across drug targets. (1/7) biorxiv.org/content/10.110…

Check out our paper on visualizing and quantifying the dynamics of CTCF/cohesin loops in living cells which is now online Science Magazine science.org/doi/10.1126/sc… MIT Dept of BE MPI-CBG Dresden Center for Systems Biology Dresden Gene Regulation Observatory Broad Institute MIT Physics

In widefield microscopy, the entire sample is illuminated at the same time

We present light-sheet microscopy combined with structured illumination. This enables rapid volumetric imaging in a light-sheet format with doubled resolution. This will need a few tweets to discuss the details... 1/n biorxiv.org/content/10.110…

Using super-resolution live-cell imaging, scientists have directly visualized chromatin looping in a living cell type. Learn more: fcld.ly/jx78hdb #ScienceResearch

Thanks Davide Michieletto Wendy Bickmore for highlighting in Molecular Cell cell.com/molecular-cell… our recent work science.org/doi/full/10.11… visualizing a TAD-forming CTCF/cohesin loop in live cells and showing these structures to be dynamic, rare, and largely partially extruded.

Many amazing new insights into the mechanisms of CTCF-mediated stalling of cohesin loop extrusion - CTCF/Cohesin never cease to amaze and surprise. DNA tension appears to play a key role. This is a must-read preprint: biorxiv.org/content/10.110…

Do you understand why this is bad? You perform experiments with some of the most vulnerable people and are casually explaining that you did this without their consent?

WOOOO Viraat Goel and Miles Huseyin !!!! Viraat Goel your greatest piece of work is this video.

Online Now: Putative looping factor ZNF143/ZFP143 is an essential transcriptional regulator with no looping function dlvr.it/TH7JsK