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New year, New lab 🐟🐟🐟

Yesterday we zoom-celebrated the formal acceptance of Hilbert et al., 2021 in Nature Communications. Official announcement will come soon. For now we say cheers from Switzerland, Germany, and Portugal 🍾 Lennart Hilbert Ksenia Kuznetsova tommaso bianucci 🍉 MPI-CBG Dresden Université de Lausanne #funwithvastenhouwies

Vienna #EMBOmzt here we come! looking forward to hearing the latest research and connecting with genome activation researchers in-person again! #funwithvastenhouwies

thanks to @PauliGroup Nadine Vastenhouw for organizing a pre-conference event & joint lab retreat. Fun day IMP for scientific discussions and socializing! #funwithvastenhouwies

thanks #EMBO & org committee Kikue Tachibana Melissa Harrison Lab Dónal O’Carroll Nadine Vastenhouw. Wonderful discussions, hearing about the ongoing research, networking & reuniting with friends&colleagues in the amazing Vienna BioCenter IMP #EMBOmzt #mzt2022

If you liked my talk on the role of transcription bodies in transcription and development at #EMBLTranscript and wanna hear more, I recommend to go and see Martino Ugolini’s poster (237) this PM. Also check out posters 85, 98 and 200.

After covid and its restrictions, lab move to Lausanne, new members joining, ⁦⁦Nadine Vastenhouw⁩ and Vastenwhouwlab were finally able to gather under one roof for a lab retreat in Annecy. 3 days of creativity, cooperativity, reflection time and #funwithvastenhouwies. 1/2

We are excited to share our latest work with you biorxiv.org/content/10.110…. Here, @martinougolini disrupted the formation of two prominent transcription bodies and found that they impact transcription genome wide. A short thread.

We are hiring! If you are interested in nuclear organization, check out our powerful system (in thread), and join us in beautiful Lausanne to address the next exciting questions. We invite applications from all areas of the life sciences, see t.ly/9GYD. Please RT.

Enlightening talk by Dr. Elizabeth Bik Elisabeth Bik today at UNIL @cig_unil Incredible how prevalent the scientific misconduct is and how little journals care about it!

Our work describing Chromatin Expansion Microscopy is now out in Science Magazine science.org/doi/10.1126/sc… Check out how we were able to visualize transcription, chromatin, and TFs with molecular resolution in developing zebrafish embryos to understand gene regulation!

Just another day at #theoffice / in the lab. Sometimes experiments just don’t go as planned. Can always count on labmates to bring sillyness & laughter: Bears. Beets. Battlestar Galactica. #funwithvastenhouwies

Fantastic work by Geetika Chouhan and others from the lab, in collaboration with S. R. Koti at TIFR and Mandar Inamdar at IIT Bombay!! Geetika shows that the epithelium formed of large cells is mechanically compromised.

How do TFs recruit the transcriptional machinery? This critical cellular function is incompletely understood. Led by postdoc Nick Morffy, we experimentally identify Arabidopsis ADs at scale and use this immense dataset to create an AD predictor, TADA. nature.com/articles/s4158…

We are excited to share our latest work: biorxiv.org/content/10.110… in which we show that local DNA compaction creates TF-DNA clusters that enable transcription.

Just out! biorxiv.org/content/10.110…. Shivali Dongre used quantitative imaging to study how gene-specific TFs cluster in the nucleus. In line with existing models, she found that both the DNA-binding domain and an intrinsically disordered region are required for clusters to form.

An expanded view of cell competition In this Review, @ameya2810 and Stephanie Ellis survey cellular selection processes across diverse physiological contexts and suggest that a broader view of the cell competition concept would benefit understanding of cell–cell interactions in

Looking for a PhD position? Interested in understanding gene regulation using live-cell single-molecule imaging technologies? Apply for the NKI PhD program to join our lab or other The Netherlands Cancer Institute labs. bit.ly/3O4bOjq

Congrats Yoatian, Henry, Denes and everyone else involved on this very beautiful work! With a special shout-out to our own Shivali Dongre who contributed some very nice zebrafish work! Université de Lausanne CIG Unil.