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#COVID19 critically ills in England, Wales & Northern Ireland ➡️ 10,834 pts overly non-white, from deprived areas more likely male/obese ➡️ 36.9% severe #ARDS P/F ≤100 ➡️ 72% invasive MV ➡️ high acute hospital mortality 42% vs other viral pneumonias 24.7% rdcu.be/b8sgN

ICNARC proud to be the Clinical Trials Unit for remap-cap in the UK. Generating findings that can help save lives across ICUs globally. medrxiv.org/content/10.110…

We estimate that the Phase 1 vaccination strategy potentially reduces numbers of patients becoming critically ill with COVID-19 substantially. For those not covered, older age remains dominant with males and some ethnic groups disproportionally represented osf.io/yks8c/

Fantastic news! We have now reached 100 patients recruited to the study in just over a month. We are so grateful for all the hard work being undertaken at every site and by the team ICNARC

Important paper on delivery of data-enabled clinical trials. Our UK-ROX Trial funded through National Institute for Health and Care Research data-enabled trials call fully utilising the Case Mix Programme to hugely reduce data collection burden on sites and maximise efficiency.

We are excited to announce that the 500th patient has been randomised into the UK-ROX trial! Huge thank you to everyone involved for all their hard work. To celebrate this milestone, we have released our first newsletter - available for download here: icnarc.org/Our-Research/S…

Please find our latest, now weekly report on patients critically ill with #Covid_19, reporting patients admitted from 1 May 2021 to date compared with patients admitted from 1 September 2020 to 30 April 2021. icnarc.org/Our-Audit/Audi…

TEAM RCT only has 15 patients to go! We have had a strong start to recruitment in November, with 4 participants from 3 countries. Great #teamwork 🎉 Keep it up! Prof Carol Hodgson TEAM

We are excited to announce that TEAM has officially completed recruitment! Thank you to all participating PIs, physios, RCs and study participants Participant #750 was recruited this morning from the wonderful TEAM at PAH Alicia Bowen Marc Nickels Prof Carol Hodgson anzicrc

#CLASSICtrial manuscript is now published NEJM nejm.org/doi/full/10.10… editorial - nejm.org/doi/full/10.10… Many thanks NEJM for facilitating the publication with the results presentation at #CCR22 @TineMeyhoff @AndersPerner @MortenHylander

Chief Investigator Prof Carol Hodgson presenting the TEAM trial results ESICM #LIVES2022 published in NEJM. Our biggest thanks to all participating sites, investigators, patients and their families. @DrStefan2 Paul Young Dr Lisa Higgins anzicrc ANZICS ICNARC Irish Critical Care Clinical Trials Network MRINZ - Medical Research Institute of New Zealand

Oxygen targets in PICU - the long awaited results of the OXY-PICU trial. Results from @pus27 & Doug Gould Thursday, June 15th, 0900 UTC+1 Join us in person or virtually criticalcarereviews.com/meetings/ccr23

.Oxy-PICU trial results presented at #CCR23 Critical Care Reviews by Prof Mark Peters and ICNARC team #PedsICU #PCCSSG

Summary of the Oxy-PICU presentation this morning from @pus27 & Doug Gould PICU Journal Watch #PedsICU #PedsCICU

Do you work in #PICU ? Please help us to design a PICU Platform Trial that is acceptable to children & YP, parents & you by taking part in a focus group. Contact [email protected] for more info. Please RT. Paediatric Critical Care Society Prof P Ramnarayan (Ram) PICU Alder Hey Edinburgh PICU Professor Kerry Woolfall

Has your child been admitted to Paediatric Intensive Care (PICU) in the last three years or are you a patient and public involvement member of a paediatric clinical trial? Please help us design a clinical trial exploring multiple treatments in PICU. Contact me for more info.

Great to see Oxy-PICU results out in The Lancet. Important UK paediatric ICU research, evaluating conservative oxygenation, funded by National Institute for Health and Care Research. @pus27 Doug Gould Prof P Ramnarayan (Ram) Samiran Ray Lauran O'Neill Kathy Rowan David Harrison thelancet.com/journals/lance…

A landmark NIHR-funded study has found that reducing oxygen levels for children in intensive care will save lives. The Oxy-PICU study was led by researchers from Great Ormond Street Hospital for Children and NIHR UCLH Biomedical Research Centre. Read more: nihr.ac.uk/news/reducing-…

Delighted to announce that Prof Kathy Rowan Kathy Rowan will deliver the 2024 John Hinds Lecture at CCR24 "ICNARC at 30 - Back to the Future" Titanic Belfast June 12-14 criticalcarereviews.com/meetings/ccr24 Josephine Hinds

Conservative oxygen therapy with a target SpO2 of 90% did not reduce 90-day all-cause mortality compared to usual oxygen therapy in mechanically ventilated adult patients. #CCR25 Critical Care Reviews ja.ma/43Ry4Ep