Amir Iravani (@drairavani) 's Twitter Profile
Amir Iravani

@drairavani

Theranostics and Molecular Imaging, #prostatecancer, #NET, @FredHutch. @UW

ID: 1218639996774580224

calendar_today18-01-2020 21:03:26

364 Tweet

693 Followers

233 Following

Michael Hofman (@drmhofman) 's Twitter Profile Photo

New Frontiers in PSMA Radioligand Therapy Is this the "hottest" session at ASCO #ASCO25 ?? ■ VIOLET: First-in-human trial of Terbium-161 ■ BULLSEYE: Lu-PSMA in oligo-metastatic disease ■ ENZA-p: Biomarkers ProsTIC PCF Science

New Frontiers in PSMA Radioligand Therapy

Is this the "hottest" session at <a href="/ASCO/">ASCO</a> #ASCO25  ??

■ VIOLET: First-in-human trial of Terbium-161
■ BULLSEYE: Lu-PSMA in oligo-metastatic disease
■ ENZA-p: Biomarkers

<a href="/pros_tic/">ProsTIC</a> <a href="/PCF_Science/">PCF Science</a>
Michael Hofman (@drmhofman) 's Twitter Profile Photo

Stunning research from Edmond Kwan on ctDNA in theranostics: 🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy ⚠️PTEN alterations linked to worse outcomes on cabazitaxel 🧪ATM defects tied to favorable PSMA-617 results 🩻PET quantitative

Stunning research from <a href="/EdmondMKwan/">Edmond Kwan</a> on ctDNA in theranostics:
🧬Low ctDNA predicts better response with ¹⁷⁷Lu-PSMA-617 vs. cabazitaxel chemotherapy
⚠️PTEN alterations linked to worse outcomes on cabazitaxel
🧪ATM defects tied to favorable PSMA-617 results
🩻PET quantitative
Edmond Kwan (@edmondmkwan) 's Twitter Profile Photo

On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the ANZUP phase II TheraP study, now published in Nature Medicine. Massive effort supported by dedicated co-investigators, coordinators, patients & families from 11 study sites across

On the eve of #ASCO25, I am delighted to share results from the correlative analyses of the <a href="/ANZUPtrials/">ANZUP</a> phase II TheraP study, now published in <a href="/NatureMedicine/">Nature Medicine</a>. Massive effort supported by dedicated co-investigators, coordinators, patients &amp; families from 11 study sites across
Michael Hofman (@drmhofman) 's Twitter Profile Photo

Getting ready for ASCO #ASCO25? ✈️🔬 There’s lots of theranostics … including a dedicated session for prostate cancer. Don’t miss these! 👀

Getting ready for <a href="/ASCO/">ASCO</a> #ASCO25? ✈️🔬

There’s lots of theranostics … including a dedicated session for prostate cancer. 

Don’t miss these! 👀
Michael Hofman (@drmhofman) 's Twitter Profile Photo

Pleased to share some first images of Lutetium-177 CA-IX peptide theranostics for metastatic clear cell renal cancer #ASCO25 ASCO. Ga-68 DPI-4452 PET/CT at baseline and on-treatment shown👇 State-of-the-Science: Novel Diagnostics and Therapeutics in Renal Cell Carcinoma

Michael Hofman (@drmhofman) 's Twitter Profile Photo

Don't miss the first-in-human VIOLET study being presented #ASCO25 ASCO Monday June 2 3:00 PM New Frontiers in Prostate-Specific Membrane Antigen Radioligand Therapy (awesome research being presented in this session - don't miss the other talks) In press The Lancet Oncology

Michael Hofman (@drmhofman) 's Twitter Profile Photo

Great to hear the patient perspective at ASCO #ASCO25 David Matheson ... His initial thought was "cut out all out" but with time to think he opted for radiotherapy...

Great to hear the patient perspective at <a href="/ASCO/">ASCO</a> #ASCO25 David Matheson ... His initial thought was "cut out all out" but with time to think he opted for radiotherapy...
Michael Hofman (@drmhofman) 's Twitter Profile Photo

ANZUP #EVOLUTION trial live at ASCO #GU25 ¹⁷⁷Lu-PSMA-617 + ipilimumab (n=67) + nivolumab vs. ¹⁷⁷Lu-PSMA-617 (n=33) ■ rPFS favouring ¹⁷⁷Lu immunotherapy: HR 0.53 (95% CI 0.32-0.90) ■ PSA-50 RR 75% vs. 67% ■ Grade 3-4 AEs 76% vs. 29% A/Prof. Shahneen Sandhu

<a href="/ANZUPtrials/">ANZUP</a> #EVOLUTION trial live at <a href="/ASCO/">ASCO</a> #GU25

¹⁷⁷Lu-PSMA-617 + ipilimumab (n=67) + nivolumab vs. ¹⁷⁷Lu-PSMA-617 (n=33)

■ rPFS favouring ¹⁷⁷Lu immunotherapy: HR 0.53 (95% CI 0.32-0.90)
■ PSA-50 RR 75% vs. 67%
■ Grade 3-4 AEs 76% vs. 29%

<a href="/SandhuShahneen/">A/Prof. Shahneen Sandhu</a>
Michael Hofman (@drmhofman) 's Twitter Profile Photo

#VIOLET Study of Terbium-161 (Tb-161) Beta/Auger therapy ASCO #ASCO25 First prospective trial of Terbium-161 in any tumour type 🟣 30 patient trial in prostate cancer. No dose limiting toxicities at highest level of radioactivity (7.4 GBq) 🟣 Very few side effects: 1 grade 3

#VIOLET Study of Terbium-161 (Tb-161) Beta/Auger therapy <a href="/ASCO/">ASCO</a> #ASCO25

First prospective trial of Terbium-161 in any tumour type
🟣 30 patient trial in prostate cancer. No dose limiting toxicities at highest level of radioactivity (7.4 GBq)
🟣 Very few side effects: 1 grade 3
Amir Iravani (@drairavani) 's Twitter Profile Photo

Very pleased to see #NucMed perspective is included in a panel discussion on the patient-centerd management of high-risk #PSMA PET N1 disease at ASCO 25, Drs Curtiland Deville (RadOnc), Alberto Birganti(SurgOnc), Alicia Morgan(MedOnc) and David Matheson(Patient ad) SNMMI

Very pleased to see #NucMed perspective is included in a panel discussion on the patient-centerd management of high-risk #PSMA PET N1 disease at <a href="/ASCO/">ASCO</a> 25, Drs Curtiland Deville (RadOnc), Alberto Birganti(SurgOnc), Alicia Morgan(MedOnc) and David Matheson(Patient ad) <a href="/SNM_MI/">SNMMI</a>
Amir Iravani (@drairavani) 's Twitter Profile Photo

#PET is a critical tool for noninvasive imaging of immune activation and #immunotherapy: Approaches to Imaging Immune Activation Using PET jnm.snmjournals.org/content/66/6/8… Thanks to co-authors! SNMMI Fred Hutch Cancer Center UW Medicine UW Radiology

#PET is a critical tool for noninvasive imaging of immune activation and #immunotherapy: Approaches to Imaging Immune Activation Using PET
 
jnm.snmjournals.org/content/66/6/8… 

Thanks to co-authors!

<a href="/SNM_MI/">SNMMI</a> <a href="/fredhutch/">Fred Hutch Cancer Center</a> <a href="/UWMedicine/">UW Medicine</a> <a href="/UWRadiology/">UW Radiology</a>